Construction of a two-dimensional DNA–RNA hybridized membrane for collecting tumor-derived exosomes

Abstract

Macroscopic nucleic acid‒based structures have attracted much attention in biomedical fields. Here, we introduce a novel DNA-RNA hybridized membrane structure via enzymatic dual polymerization. The membrane exhibited enhanced rigidity and...

Self-Healing and Thermal Responsive DNA Bioplastics for On-Demand Degradable Medical Devices

“…Among these sources, nucleic acids, as biomacromolecule, have garnered significant attention as potential candidate to fulfill the desired properties of the ideal Bioplastic, including on-demand degradability for ideal bioplastics. − In this regard, nucleic acid, which is found to be universally present in all organisms and present throughout ecosystems, offers substantial potential as an abundant plastic resource derived from biomass . Previous studies have demonstrated the versatility of nucleic acids as biomolecular building blocks for constructing macroscale structures through various approaches. − Notably, attempts to create DNA-based cross-linked structures have employed methods such as DNA branching, − metal doping, and enzymatic amplification . However, achieving the desired level of mechanical properties for practical applications remains a challenge, as these structures typically exhibit low storage–loss modulus in the range of a few thousand to hundreds of pascals and are limited in manufacturing capabilities, primarily restricted to molding processes.…”