Construction of a microRNA–mRNA Regulatory Network in De Novo Cytogenetically Normal Acute Myeloid Leukemia Patients

Comprehensive analysis of cuproptosis-associated LncRNAs predictive value and related CeRNA network in acute myeloid leukemia

“…Due to the lack of corresponding miRNA expression data in the TCGA-LAML and GTEx datasets, we searched PubMed for studies on these miRNAs in AML. From previous literature, the expression of miR-93-5p [ 26 , 27 ], miR-124-3p [ 28 , 29 ], miR-185-5p [ 30 , 31 ], miR-20a-5p [ 32 , 33 ], and miR-17-5p [ 34 , 35 ] differs in AML patients compared to healthy controls. Meanwhile, miR-106a-5p was consistently overexpressed in settings where AML was resistant to therapy.…”

“…Interestingly, our research findings revealed that TRAF3IP2-AS1 may regulate the expression of MTF1 SLC31A1, PGD, G6PD, and LPCAT3 by targeting miRNAs associated with myeloid differentiation, drug resistance, treatment failure, proliferation, and invasion of AML [ [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] ]. Moreover, TRAF3IP2-AS1 was negatively correlated with these mRNAs as a protective factor.…”

The potential role of serum extracellular vesicle derived small RNAs in AML research as non-invasive biomarker

“…40 MiR-185-5p was shown to be associated with the negative regulation of myeloid leukocyte differentiation, negative regulation of myeloid cell differentiation, and positive regulation of hematopoiesis in the regulation of CN-AML. 41 MiR-199a-5p was shown to play an important role in regulating the sensitivity of AML cells to Adriamycin (ADM) treatment. 42 Concerning EV derived miRNAs (Table 4), miR-10a-5p was signicantly increased in MDS, prostate cancer (PCa) and human immunodeciency virus (HIV) patients compared to controls in plasma derived EVs.…”

“…40 MiR-185-5p was shown to be associated with the negative regulation of myeloid leukocyte differentiation, negative regulation of myeloid cell differentiation, and positive regulation of hematopoiesis in the regulation of CN-AML. 41 MiR-199a-5p was shown to play an important role in regulating the sensitivity of AML cells to Adriamycin (ADM) treatment. 42…”

Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML

“…Therefore, mathematical modeling of the underlying GRN of AML and the effects of genetic perturbation can elucidate the gene regulation of the disease process and shed lights on new therapeutic strategies for AML. Some recent GRN modeling studies made efforts to elucidate AML gene regulation [6][7][8][9][10][11][12] . For example, Wooten et al constructed a GRN of 106 nodes and 270 edges by composing interactions from different sources (e.g., SIGNOR) and performed Boolean modeling of the network to study drug response in class I FLT3 mutated AML 11 .…”