Construction of a digital and physical mouse model aimed at the study of electrical shock

Abstract

Optical methods have been used to investigate electrical injury on animal models such as live mice, rats, and rabbits. Here we introduce a completely digital phantom of a mouse, with the aim of investigating electrical injury through spectroscopic imaging techniques. The basis of our phantom is a three-dimensional digital mouse reconstructed from co-registered computed tomographic images and cryosection by a different group. Image processing algorithms were applied to make the model suitable to Finite Element Analysis of thermal and electrical transport. Our digital model is capable of simulating temperature, voltage, current changes along the animal body during and after electrical shocks.

Ανάπτυξη Μεθόδων / Τεχνικών Για Τη Δοσιμετρία Στη Στοχευμένη Φωτοδυναμική Θεραπεία

“…Τα πρώτα 5 min της ακτινοβόλησης η θερμοκρασία έχει ανέλθει στο 75% της μέγιστης τιμής της. είναι είτε υπεραπλουστευτικά[177] είτε προέρχονται από δεδομένα που έχουν ληφθεί με απεικονιστικές τεχνικές ζωντανών μυών[178].…”