1992
DOI: 10.1128/jvi.66.7.4470-4478.1992
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Abstract: Interferon (IFN)-stimulated gene factor 2 (ISGF2) plays a role in transcription of the beta IFN (IFN-beta) gene and IFN-stimulated genes (ISGs) and may function as a central mediator of cytokine responses. Constitutive ISGF2 transgene expression resulted in substantial resistance to three RNA virus families. This phenotype was not a consequence of IFN production and may have arisen directly through ISG expression. ISGF2 acted generally as a positive transcription factor through binding sites from several genes… Show more

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Cited by 123 publications
(31 citation statements)
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References 65 publications
(31 reference statements)
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“…5b, the inhibition of protein synthesis significantly affected the level of STAT3 activation, in the absence of reduction of both STAT3 and ␤-tubulin proteins. The effectiveness in blocking the protein synthesis was proven by the dropping of the rNef-induced IRF-1 contents, whose half-life was reportedly ϳ30 min [45]. We concluded that the release of de novo synthesized soluble factors was involved in the Nefdependent STAT3 activation in MDM.…”
Section: Critical Events For the Nef-dependent Stat3 Activation Occurmentioning
confidence: 80%
“…5b, the inhibition of protein synthesis significantly affected the level of STAT3 activation, in the absence of reduction of both STAT3 and ␤-tubulin proteins. The effectiveness in blocking the protein synthesis was proven by the dropping of the rNef-induced IRF-1 contents, whose half-life was reportedly ϳ30 min [45]. We concluded that the release of de novo synthesized soluble factors was involved in the Nefdependent STAT3 activation in MDM.…”
Section: Critical Events For the Nef-dependent Stat3 Activation Occurmentioning
confidence: 80%
“…Among these, IRF1 is a prominent antiviral effector against numerous viruses. IRF1 was originally characterized nearly 20 years ago in a study demonstrating that it exerts antiviral functions in the absence of IFN [35]. In support of this observation, the expression of IRF1 in human STAT1 À/À fibroblasts results in the induction of more than 100 genes, the majority of which are ISGs, but not IFN genes [22 ].…”
Section: Mechanisms Of Action: Virus Life Cycle and Host Processesmentioning
confidence: 88%
“…the presence of IRF-1 contributes to the constitutive expression of MHC/HLA genes (11). Its overexpression leads to the activation of MHC class I proteins, 2'5' oligo A synthetase and ISG-15 (9,11,12,13). It also is able to induce the complete set of anti-viral activities which is believed to require transcriptional activation of ISGs (13).…”
Section: Introductionmentioning
confidence: 99%