Biochemical Pharmacology volume 80, issue 1, P129-135 2010 DOI: 10.1016/j.bcp.2010.02.023 View full text
Kosuke Saito, Kaoru Kobayashi, Yuki Mizuno, Tomomi Furihata, Kan Chiba

Abstract: Nuclear receptor constitutive androstane/active receptor (CAR) is well known as a transcription factor regulating many genes that encode drug-metabolizing enzymes and factors modulating hepatic gluconeogenesis. However, there have been few studies on regulation of the CAR gene itself. In this study, we examined the involvement of retinoic acid receptor alpha (RAR alpha) in transcriptional regulation of the CAR gene in the liver. The expression levels of CAR mRNA in human primary hepatocytes and HepG2 cells wer…

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