Constituents of leaves and branches of Helietta parvifolia

Antimycobacterial Compounds from Piper sanctum

“…HPLC purification of the oils allowed the isolation of safrol (25). 23 Compounds 1-4 had the molecular formulas of . In all cases the substitution pattern of the aromatic ring was confirmed by the correlations observed in the NOESY and HMBC spectra.…”

“…The essential oil of the leaves and the stem were prepared by hydrodistillation. HPLC purification of the oils allowed the isolation of safrol ( 25 )

1 Crystal structure of 17 .

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“…Bioassay-guided chromatographic separation of the antimycobacterial extract of the leaves of Piper sanctum afforded 14 new compounds, identified as 2-oxo-12-(3′,4′-methylenedioxyphenyl)dodecane (1), 2-oxo-14-(3′,4′-methylenedioxyphenyl)tetradecane (2), 2-oxo-16-(3′,4′-methylenedioxyphenyl)hexadecane (3), 2-oxo-18-(3′,4′-methylenedioxyphenyl)octadecane (4), 2-oxo-14-(3′,4′-methylenedioxyphenyl)-trans-13tetradecene (5), 2-oxo-16-(3′,4′-methylenedioxyphenyl)-trans-15-hexadecene (6), 2-oxo-18-(3′,4′-methylenedioxyphenyl)-trans-17-octadecene (7), 2-oxo-16-phenyl-trans-3-hexadecene (8), methyl [6-(10-phenyldecanyl)tetrahydropyran-2-yl]acetate (9), methyl 2-(6-tridecyltetrahydro-2H-pyran-2-yl)acetate (10), methyl 2-(5-tetradecyltetrahydro-2-furanyl)acetate ( 11), 2-oxo-14-(3′,4′-methylenedioxyphenyl)-trans-3tetradecene (12), 2-oxo-16-(3′,4′-methylenedioxyphenyl)-trans-3-hexadecene ( 13), and 2-oxo-16-phenyl-3hexadecane (14). In addition, p-eugenol (15), methyleugenol (16), Z-piperolide (17), demethoxyyangonin (18), 5,6-dehydro-7,8-dihydromethysticin (19), cepharanone B (20), piperolactam A (21), cepharadione B (22), N-trans-feruloyltyramine (23), and N-trans-(p-coumaroyl)tyramine (24) were obtained from the anti-TBC stem extract of the plant. GC-MS and HPLC analyses of the essential oils of the leaves and stem revealed that safrol (25) was the major component of the oils.…”