Constituents of an Extract of <i>Cryptocarya rubra</i> Housed in a Repository with Cytotoxic and Glucose Transport Inhibitory Effects

Ren, Yulin; Yuan, Chunhua; Qian, Yanrong; Chai, Heebyung; Chen, Xiaozhuo; Goetz, Michael; Kinghorn, A. Douglas

doi:10.1021/np400809w

Cited by 37 publications

(52 citation statements)

References 32 publications

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“…1) has been recently identified among the components of an extract isolated from the leaves and twigs of Cryptocarya rubra, a tropical plant belonging to the Lauraceae family. 15 This extract was found to be cytotoxic on HT-29 human colon cancer cells, as widely reported in the literature, where there are many evidences of the cytotoxicity of this dihydrochalcone on cancer cell lines, such as its ability to induce apoptosis through activation of caspases in prostate tumor. 16,17 Consistent with previous data, compound 2 showed an IC 50 value of 0.32 lM on HT-29 cells, and was found to cause a significant reduction of the uptake of glucose, implying that its anti-proliferative activity could be ascribed, at least in part, to GLUT inhibition.…”

Section: Introductionsupporting

confidence: 54%

An update on therapeutic opportunities offered by cancer glycolytic metabolism

Granchi

Fancelli

Minutolo

2014

Bioorganic & Medicinal Chemistry Letters

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Almost all invasive cancers, regardless of tissue origin, are characterized by specific modifications of their cellular energy metabolism. In fact, a strong predominance of aerobic glycolysis over oxidative phosphorylation (Warburg effect) is usually associated with aggressive tumour phenotypes. This metabolic shift offers a survival advantage to cancer cells, since they may continue to produce energy and anabolites even when they are exposed to either transient or permanent hypoxic conditions. Moreover, it ensures a high production rate of glycolysis intermediates, useful as building blocks for fast cell proliferation of cancer cells. This peculiar metabolic profile may constitute an ideal target for therapeutic interventions that selectively hit cancer cells with minimal residual systemic toxicity. In this review we provide an update about some of the most recent advances in the discovery of new bioactive molecules that are able to interfere with cancer glycolysis.

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Section: Introductionsupporting

confidence: 54%

An update on therapeutic opportunities offered by cancer glycolytic metabolism

Granchi

Fancelli

Minutolo

2014

Bioorganic & Medicinal Chemistry Letters

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“…Such a reaction requires reflux at an elevated temperature or takes a longer time at room temperature. 55,56,99 However, with a nucleophile substitution on the α -position, mild conditions are generally sufficient (Table 2, entry 3). 100 …”

Section: Synthesismentioning

confidence: 99%

Chalcone: A Privileged Structure in Medicinal Chemistry

et al. 2017

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Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

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“…(Lauraceae), was found to exhibit potent cytotoxicity against HT‐29 human colon cancer cells, with an IC 50 value of 0.32 μM. At a concentration of 30 μM, this compound inhibited significantly glucose transport in H1299 human lung cancer cells, indicating that it may mediate its cytotoxicity at least in part through interaction with GLUTs (Ren et al, ).…”

Section: Flavonoid Glucose Transport Inhibitorsmentioning

confidence: 99%

Plant‐derived glucose transport inhibitors with potential antitumor activity

Shriwas

Chen

Kinghorn

et al. 2019

Phytotherapy Research

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Glucose, a key nutrient utilized by human cells to provide cellular energy and a carbon source for biomass synthesis, is internalized in cells via glucose transporters that regulate glucose homeostasis throughout the human body. Glucose transporters have been used as important targets for the discovery of new drugs to treat cancer, diabetes, and heart disease, owing to their abnormal expression during these disease conditions. Thus far, several glucose transport inhibitors have been used in clinical trials, and increasing numbers of natural products have been characterized as potential anticancer agents targeting glucose transport. The present review focuses on natural product glucose transport inhibitors of plant origin, including alkaloids, flavonoids and other phenolic compounds, and isoprenoids, with their potential antitumor properties also discussed.

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Constituents of an Extract of Cryptocarya rubra Housed in a Repository with Cytotoxic and Glucose Transport Inhibitory Effects

Cited by 37 publications

References 32 publications

An update on therapeutic opportunities offered by cancer glycolytic metabolism

An update on therapeutic opportunities offered by cancer glycolytic metabolism

Chalcone: A Privileged Structure in Medicinal Chemistry

Plant‐derived glucose transport inhibitors with potential antitumor activity

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