CONSORT: when and how to use it

Falci, Saulo Gabriel Moreira; Marques, Leandro Silva

doi:10.1590/2176-9451.20.3.013-015.ebo

Cited by 58 publications

(35 citation statements)

References 13 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, a variety of extensions exist making the CONSORT guidelines applicable for a variety of research designs. Though the guidelines are not intended to assess studies' quality (Schulz et al, 2010), they have been previously proven useful in assessing quality of studies (Falci & Marques, 2015).…”

Section: Relevance the Journal Of Consulting And Clinical Psychologymentioning

confidence: 99%

Replication Target Selection in Clinical Psychology: A Bayesian and Qualitative Re-evaluation

Pittelkow¹,

Hoekstra²,

Karsten³

et al. 2020

Preprint

View full text Add to dashboard Cite

Low rates of replication in clinical psychological research can have serious implications for clinical practice. We aim to (1): assess the strength of statistical evidence for primary findings in a journal representative of clinical psychology using Bayesian statistics, and (2) take a pragmatic approach to dealing with the question of which studies to replicate by proposing a two-step process. This process entails a quantitative assessment of the strength of evidence using Bayes factors, and a qualitative assessment of underlying theory and methodology. We provide proof of concept utilizing papers published in the Journal of Consulting and Clinical Psychology between 2012 and 2016. A total of 75 studies yielding 94 effects were included. Step 1 yielded 52 effects (55.32%) for which Bayes Factors provided strong support for the claimed effect. For the other 42 effects (44.68%), Bayes Factors suggested only modest evidence or even evidence of an absence of an effect. In step 2, these 42 effects were assessed on qualitative grounds independently by two raters. We discuss their recommendations, illustrate their decision process, and discuss the advantages and disadvantages of employing the proposed two-step process. Such an approach could benefit the field and enhance evidence-based treatment.

show abstract

Section: Relevance the Journal Of Consulting And Clinical Psychologymentioning

confidence: 99%

Replication Target Selection in Clinical Psychology: A Bayesian and Qualitative Re-evaluation

Pittelkow¹,

Hoekstra²,

Karsten³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Viral culture technique should be employed in future in vivo research so as to establish the true potential of viral infectivity. In addition, guidelines to conduct in vitro studies, e.g., Preferred Reporting Items for Laboratory studies in Endodontology (PRILE), and clinical trials, e.g., Preferred Reporting Items for Randomized Trials in Endodontics (PRIRATE) or Consolidated Standards of Reporting Trials (CONSORT), should be followed (66)(67)(68).…”

Section: Future Recommendationsmentioning

confidence: 99%

Efficacy of Mouth Rinses Against SARS-CoV-2: A Scoping Review

2021

View full text Add to dashboard Cite

Introduction: The presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in saliva and nasopharyngeal secretions has challenged the routine practice of dentistry. Use of preprocedural mouth rinses has been recommended by several organizations to potentially reduce the transmission of SARS-CoV-2. This scoping review aimed at evaluating the available evidence on the efficacy of mouth rinses against SARS-CoV-2.Methods: A thorough literature search on electronic databases (PubMed, Scopus, and Google Scholar) was performed by two independent reviewers and data from articles addressing the aim of this article were extracted.Results: After exclusion of articles not addressing the end point in question, 12 articles were included in this scoping review. Of the 12 articles, seven were in vitro studies and five were in vivo human clinical studies. The in vitro studies used a standardized methodology (endpoint dilution assay) to evaluate the efficacy of antimicrobial mouth rinses against SARS-CoV-2. The in vivo studies were done utilizing polymerase chain reaction assay of samples obtained from saliva or nasopharyngeal swab or a combination of both nasopharyngeal and oropharyngeal swab. The reagents tested in these studies included povidone-iodine, chlorhexidine, hydrogen peroxide (H2O2), essential oils, and quaternary ammonium compounds and demonstrated varied efficacy against SARS-CoV-2.Conclusion: Based on the available evidence from in vitro studies, it can be concluded that mouth rinses have a potential to reduce SARS-CoV-2 viral load; however, effectiveness in in vivo conditions is still inconclusive. Owing to the substantial heterogeneity in reporting of the anti–SARS-CoV-2 efficacy of mouth rinses, this review highlights the need to conduct future research with robust and standardized methodologies to confirm effectiveness of mouth rinses.

show abstract

“…The primary studies included in the final analysis will be appraised for quality using CONSORT 15 (randomized), STROBE 16 (observational), QUADAS-2 (DTA) studies, 17 and against the criteria in the CARNet white paper for studies of dCA. 2 Two centers will independently appraise studies and a third center will mediate disagreements in quality assessment.…”

Section: Primary Study Quality and Risk Of Bias Assessmentmentioning

confidence: 99%

INFOMATAS multi-center systematic review and meta-analysis individual patient data of dynamic cerebral autoregulation in ischemic stroke

Beishon

Minhas

Nogueira

et al. 2020

International Journal of Stroke

View full text Add to dashboard Cite

Rationale Disturbances in dynamic cerebral autoregulation after ischemic stroke may have important implications for prognosis. Recent meta-analyses have been hampered by heterogeneity and small samples. Aim and/or hypothesis The aim of study is to undertake an individual patient data meta-analysis (IPD-MA) of dynamic cerebral autoregulation changes post-ischemic stroke and to determine a predictive model for outcome in ischemic stroke using information combined from dynamic cerebral autoregulation, clinical history, and neuroimaging. Sample size estimates To detect a change of 2% between categories in modified Rankin scale requires a sample size of ∼1500 patients with moderate to severe stroke, and a change of 1 in autoregulation index requires a sample size of 45 healthy individuals (powered at 80%, α = 0.05). Pooled estimates of mean and standard deviation derived from this study will be used to inform sample size calculations for adequately powered future dynamic cerebral autoregulation studies in ischemic stroke. Methods and design This is an IPD-MA as part of an international, multi-center collaboration (INFOMATAS) with three phases. Firstly, univariate analyses will be constructed for primary (modified Rankin scale) and secondary outcomes, with key co-variates and dynamic cerebral autoregulation parameters. Participants clustering from within studies will be accounted for with random effects. Secondly, dynamic cerebral autoregulation variables will be validated for diagnostic and prognostic accuracy in ischemic stroke using summary receiver operating characteristic curve analysis. Finally, the prognostic accuracy will be determined for four different models combining clinical history, neuroimaging, and dynamic cerebral autoregulation parameters. Study outcome(s) The outcomes for this study are to determine the relationship between clinical outcome, dynamic cerebral autoregulation changes, and baseline patient demographics, to determine the diagnostic and prognostic accuracy of dynamic cerebral autoregulation parameters, and to develop a prognostic model using dynamic cerebral autoregulation in ischemic stroke. Discussion This is the first international collaboration to use IPD-MA to determine prognostic models of dynamic cerebral autoregulation for patients with ischemic stroke.

show abstract

CONSORT: when and how to use it

Cited by 58 publications

References 13 publications

Replication Target Selection in Clinical Psychology: A Bayesian and Qualitative Re-evaluation

Replication Target Selection in Clinical Psychology: A Bayesian and Qualitative Re-evaluation

Efficacy of Mouth Rinses Against SARS-CoV-2: A Scoping Review

INFOMATAS multi-center systematic review and meta-analysis individual patient data of dynamic cerebral autoregulation in ischemic stroke

Contact Info

Product

Resources

About