Abstract:The classical Philadelphia chromosome-negative myeloproliferative neoplasms consist of three main pathological and clinical entities with the recurrent JAK2 V617F mutation present in ∼98% of patients with polycythemia vera and ∼50% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). The recent discovery of mutations within the CALR gene in up to 80% of JAK2 V617F-negative ET and PMF patients compels employment of CALR mutational analysis for the molecular diagnosis of these disease… Show more
“…CALR has already proven to be useful for MPN diagnostics and has been recently put up as a candidate for the future WHO diagnostic criteria of MPN [15,40].…”
“…CALR has already proven to be useful for MPN diagnostics and has been recently put up as a candidate for the future WHO diagnostic criteria of MPN [15,40].…”
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