Consideration of Multiple Sclerosis in Relation to the Auto-Immunity Process

Clinical significance of immunopathological mechanisms in diseases of the nervous system

“…Numerous tests for circulating antibodies were carried out before EF became available (see McAlpine, Lumsden & Acheson, 1965;Lisak et al, 1968). Crude antigens consisting of brain suspensions or saline or alcoholic extracts were used and the results were confiicting, although MS brain seemed to be a better antigen than normal brain (Lumsden, 1961). McAlpine and associates in a careful review of the available evidence concluded that patients with MS probably do produce antibodies to brain tissue but the nature of the antigens and the relevance of the antibodies are uncertain.…”

Clinical significance of immunopathological mechanisms in diseases of the nervous system

“…Numerous tests for circulating antibodies were carried out before EF became available (see McAlpine, Lumsden & Acheson, 1965;Lisak et al, 1968). Crude antigens consisting of brain suspensions or saline or alcoholic extracts were used and the results were confiicting, although MS brain seemed to be a better antigen than normal brain (Lumsden, 1961). McAlpine and associates in a careful review of the available evidence concluded that patients with MS probably do produce antibodies to brain tissue but the nature of the antigens and the relevance of the antibodies are uncertain.…”

Clinical significance of immunopathological mechanisms in diseases of the nervous system

“…Numerous tests for circulating antibodies were carried out before EF became available (see McAlpine, Lumsden & Acheson, 1965;Lisak et al, 1968). Crude antigens consisting of brain suspensions or saline or alcoholic extracts were used and the results were confiicting, although MS brain seemed to be a better antigen than normal brain (Lumsden, 1961). McAlpine and associates in a careful review of the available evidence concluded that patients with MS probably do produce antibodies to brain tissue but the nature of the antigens and the relevance of the antibodies are uncertain.…”

Clinical significance of immunopathological mechanisms in diseases of the nervous system

“…Numerous tests for circulating antibodies were carried out before EF became available (see McAlpine, Lumsden & Acheson, 1965;Lisak et al, 1968). Crude antigens consisting of brain suspensions or saline or alcoholic extracts were used and the results were confiicting, although MS brain seemed to be a better antigen than normal brain (Lumsden, 1961). McAlpine and associates in a careful review of the available evidence concluded that patients with MS probably do produce antibodies to brain tissue but the nature of the antigens and the relevance of the antibodies are uncertain.…”