volume 83, issue 4, P735-745 2015
DOI: 10.1002/prot.24755
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Abstract: Δ-distance maps can detect local remodeling that is difficult to accurately determine using superimpositions. TMSs 11 in both LacY and XylE of the Major Facilitator Superfamily (MFS) uniquely contribute the greatest amount of mobile surface area in the outward occluded state, and undergo analogous movements. The intracellular part of TMS11 moves away from the C-terminal domain and into the substrate cavity during the conformational change from the outward occluded to the inward occluded state. Upon releasing …

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