Conservative Management of Acoustic Neuroma: An Outcome Study

Deen, H. Gordon; Ebersold, Michael J.; Harner, Stephen G.; Beatty, Charles W.; Marion, Mitchell S.; Wharen, Robert E.; Green, J D; Quast, Lynn M.

doi:10.1097/00006123-199608000-00005

Cited by 133 publications

(88 citation statements)

References 17 publications

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“…13) An increase in growth rate during the 1st year of observation may be predictive of growth in the following year. 4,8) Cystic formation, as observed during tumor enlargement in our patient, may also contribute to significant tumor growth. 5) The mechanisms of cyst formation in vestibular schwannomas are unknown.…”

Section: Discussionmentioning

confidence: 57%

“…2,4,6,8,14,16) Tumor growth in patients with failed conservative management was 3.0-4.2 mm/year. 8,14,16) Our patient showed rapid tumor growth of 3.2 mm/year in the 1st and 2nd years of follow-up and she complained of worsening symptoms. Our patient could have been a candidate for surgery or radiotherapy if the tumor had not regressed spontaneously, as any delay leads to unfavorable outcome.…”

Section: Discussionmentioning

confidence: 99%

“…4,[6][7][8][12][13][14][15][16][17][18] These benign tumors grow slowly at less than 2 mm/year in most patients. 4,8,12,[14][15][16][17][18] Significant tumor growth occurred in 38.9-82% of the patients, no or insignificant growth in 12-47%, and negative growth in 2.8-19.4%. 4,6,7,10,[14][15][16][17][18] An extensive review of 26 studies including 1340 patients found that the overall frequency of growth was 46% and that of regression was 8%.…”

Section: Introductionmentioning

confidence: 99%

“…7) However, spontaneous regression is rare. 4,[6][7][8]10,[14][15][16][17][18] We report a case of spontaneous regression of a growing vestibular schwannoma during an 11-year follow-up period.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Regression of a Growing Vestibular Schwannoma-Case Report-

Yasumoto

Ito

2006

Neurol. Med. Chir.(Tokyo)

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A 75-year-old woman presented with a small right vestibular schwannoma which enlarged and then spontaneously regressed during conservative management. The tumor increased in size from 5.2 to 16.7 mm over 7 years with worsening symptoms of tinnitus, dizziness, and headache. The tumor then regressed to 8.2 mm and the symptoms improved for 4 years without further treatment. Changes in tumor growth should be carefully monitored during conservative management of patients with vestibular schwannoma.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spontaneous Regression of a Growing Vestibular Schwannoma-Case Report-

Yasumoto

Ito

2006

Neurol. Med. Chir.(Tokyo)

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“…Mientras que la observación con RNM seriadas se recomienda frecuentemente para los pacientes mayores con tumores pequeños 9,26 , en los pacientes jóvenes con buen estado de salud y tumores grandes se recomienda normalmente la resección quirúrgica.…”

Section: Estado Actual Del Tratamiento Del Svunclassified

Calidad de vida tras la cirugía del schwannoma vestibular

Alfonso

Lassaletta

Sarriá

et al. 2007

Acta Otorrinolaringológica Española

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Estimation of growth rate in patients with head and neck paragangliomas influences the treatment proposal

Jansen

Berg

Kuiper

et al. 2000

Cancer

255

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BACKGROUND Extraadrenal paragangliomas of the head and neck are tumors with variable clinical behavior. Because tumor growth as well as surgery can cause disabling loss of function, knowledge of the natural history of paragangliomas is important for the development of treatment strategies. METHODS The tumor volume, growth rate, and tumor doubling time of 48 paragangliomas at different anatomic locations in the head and neck region were estimated retrospectively using sequential radiologic imaging. RESULTS During a mean follow‐up period of 4.2 years, a volume increase of > 20% was observed in 60% of the paragangliomas. In these cases the median growth rate was 1.0 mm/year and the median tumor doubling time was 4.2 years. More growing tumors were observed in intermediate size tumors than in very small or large paragangliomas, suggesting a biphasic growth pattern. CONCLUSIONS The majority of head and neck paragangliomas have a very low growth rate. Although management of paragangliomas also is determined by other parameters, preoperative estimation of the tumor doubling time may influence the treatment proposal. A “wait and scan” policy must be considered in all cases. Cancer 2000;88:2811–6. © 2000 American Cancer Society.

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Conservative Management of Acoustic Neuroma: An Outcome Study

Abstract: Observation is a reasonable management strategy in carefully selected patients with acoustic neuromas. Diligent follow-up with serial magnetic resonance imaging is recommended, because some tumors will enlarge to the point at which active treatment is required.

Cited by 133 publications

References 17 publications

Spontaneous Regression of a Growing Vestibular Schwannoma-Case Report-

Spontaneous Regression of a Growing Vestibular Schwannoma-Case Report-

Calidad de vida tras la cirugía del schwannoma vestibular

Estimation of growth rate in patients with head and neck paragangliomas influences the treatment proposal

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