1993
DOI: 10.1111/j.1574-6968.1993.tb06524.x
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Conservation of surface epitopes inPseudomonas aeruginosaouter membrane porin protein OprF

Abstract: The outer membrane proteins of several prominent bacterial pathogens demonstrate substantial variation in their surface antigenic epitopes. To determine if this was also true for Pseudomonas aeruginosa outer membrane protein OprF, gene sequencing of a serotype 5 isolate was performed to permit comparison with the published serotype 12 oprF gene sequence. Only 16 nucleotide substitutions in the 1053 nucleotide coding region were observed; none of these changed the amino acid sequence. A panel of 10 monoclonal a… Show more

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Cited by 17 publications
(2 citation statements)
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References 26 publications
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“…OprF is highly conserved in pseudomonads, allowing the passage of small molecules across the outer membrane, and has been studied extensively as a vaccine candidate (15,35,36). Porins have also been described as acceptor molecules for C3b in Salmonella enterica serovar Typhimurium, Klebsiella pneumoniae, Neisseria meningitidis, and Legionella pneumophila (28,(37)(38)(39).…”
Section: Discussionmentioning
confidence: 99%
“…OprF is highly conserved in pseudomonads, allowing the passage of small molecules across the outer membrane, and has been studied extensively as a vaccine candidate (15,35,36). Porins have also been described as acceptor molecules for C3b in Salmonella enterica serovar Typhimurium, Klebsiella pneumoniae, Neisseria meningitidis, and Legionella pneumophila (28,(37)(38)(39).…”
Section: Discussionmentioning
confidence: 99%
“…Outer-membrane protein E (OMP E) is a porin and is involved in the binding and transport of fatty acids. Gene sequence analysis showed that the ompE gene stayed stable during the colonization process ( Martin et al, 1993 ). OMP E also expressed a highly conserved surface epitope ( Bhushan et al, 1997 ).…”
Section: Vaccines Against Ommentioning
confidence: 99%