volume 66, issue 7, P4364-4376 1992
DOI: 10.1128/jvi.66.7.4364-4376.1992
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Abstract: Picornavirus genomes encode unique 5' noncoding regions (5' NCRs) which are-600 to 1,300 nucleotides in length, contain multiple upstream AUG codons, and display the ability to form extensive secondary structures. A number of recent reports have shown that picornavirus 5' NCRs are able to facilitate cap-independent internal initiation of translation. This mechanism of translation occurs in the absence of viral gene products, suggesting that the host cell contains the necessary components for the cap-independen…

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