Consequences of hypogammaglobulinemia and steroid therapy in severe bronchopulmonary dysplasia

Predischarge death or lung transplantation in tracheostomy and ventilator dependent grade 3 bronchopulmonary dysplasia

“…This comorbidity appears to be associated with the use of high doses of systemic corticosteroids to treat progressive cardiopulmonary failure, resulting in an increased frequency of infection. Replacement therapy with IVIG or subcutaneous IG has resulted in improved outcomes in this population of BPD patients 32 . We speculate that in immunosuppressed lung transplant recipients, IG replacement may reduce the severity of chronic lung rejection, thus leading to prolonged posttransplant survival.…”

“…Replacement therapy with IVIG or subcutaneous IG has resulted in improved outcomes in this population of BPD patients. 32 We speculate that in immunosuppressed lung transplant recipients, IG replacement may reduce the severity of chronic lung rejection, thus leading to prolonged posttransplant survival. This possibility is worthy of future investigation.…”

“…The comorbidity of hypogammaglobulinemia G has been previously described in severe or grade 3 BPD requiring home mechanical ventilation. 9,32 This comorbidity appears to be associated with the use of high doses of systemic corticosteroids to treat progressive cardiopulmonary failure, resulting in an increased frequency of infection. Replacement therapy with IVIG or subcutaneous IG has resulted in improved outcomes in this population of BPD patients.…”

“…This need reflects the underlying burden of lung disease. The comorbidity of hypogammaglobulinemia G has been previously described in severe or grade 3 BPD requiring home mechanical ventilation 9,32 . This comorbidity appears to be associated with the use of high doses of systemic corticosteroids to treat progressive cardiopulmonary failure, resulting in an increased frequency of infection.…”

A 24-year-old woman with episodes of shortness of breath, cough and wheezing

“…20 The use of intravenous immunoglobulin has been reported to be of benefit in infants with recurrent infection; again, there are no data to support this treatment in adults. 21 Bronchopulmonary dysplasia is an indication for lung transplant in infants, and there is a case report of lung transplant in a 19-year-old patient with BPD. 22 With improvements in the understanding of mechanisms of lung repair and inflammation in BPD, new treatment strategies are being explored.…”