Consensus Recommendations for Treatment for Dogs with Serology Positive Glomerular Disease

Goldstein, Richard E.; Brovida, C.; Palacio, M.; Littman, Meryl P.; Polzin, David J.; Zatelli, Andrea; Cowgill, Larry D

doi:10.1111/jvim.12232

Cited by 27 publications

(28 citation statements)

References 21 publications

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“…Dogs with suspected LN were younger (53 % < 5 years with an average of 5.6 years) than dogs with similar diseases of different genesis (7.1 years for glomerulonephritis and 7.8 years for amyloidosis). There was no gender predisposition, and the animals were usually presented in summer and autumn with acute or chronic kidney disease accompanied by anorexia, vomitus, thromboembolism, hypertension, oedema, oliguria or pigmenturia (Dambach et al 1997;Littman et al 2006;Chou et al 2006;Goldstein et al 2013;Littman 2013). Clinical signs associated with the central nervous system (CNS) can also occur in association with nephropathy, for example as a consequence of vasculitis, hypertension, thromboembolism and uraemic encephalopathy.…”

Section: S31mentioning

confidence: 97%

“…Dogs with glomerulonephritis and suspected LN may require a longer period of doxycycline administration. In such cases (UPC above 0.5), specific recommendations regarding treatment and monitoring can be found in Goldstein et al (2013).…”

Section: S44mentioning

confidence: 98%

“…A further open question remains as to whether the specific immune complexes cause LN or are only passively deposited there (or not adequately eliminated) due to hostpathogen factors such as the Borrelia spp. strain, genetic podocytopathies or immunopathological changes (Littman 2013 Goldstein et al 2013) LN, although some attempts to fill this gap were made in the past. Despite monthly tick prophylaxis, a study group of dogs showed 18.7 % seropositivity using a C6-antibody-based test (SNAP ® 3Dx ® ), but no correlation with microalbuminuria (present in 6.1 %; E.R.D.…”

Section: S31mentioning

confidence: 99%

“…** cutoff according toGoldstein et al 2013 and www.iris-kidney.com; methods in brief: creatinine determination in mg/dl by means of the Jaffe method (blank corrected, kinetic and photometric), determination of protein in mg/dl, turbidimetric (505 nm) after the addition of benzethonium chloride…”

mentioning

confidence: 99%

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Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis

et al. 2015

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Tick-borne diseases (TBD) in dogs have gained in significance in German and Austrian veterinary practices. The widespread European tick species Ixodes ricinus represents an important vector for spirochaetes of the Borrelia burgdorferi sensu lato group and Rickettsiales such as Anaplasma phagocytophilum. The meadow or ornate dog tick (Dermacentor reticulatus) is an important vector for Babesia canis, as is the brown dog tick (Rhipicephalus sanguineus) for Babesia vogeli in the Mediterranean region. The present work covers pathogen transmission by tick vectors, including the mechanisms and the minimum intervals required, in conjunction with possible non-vector-borne transmission routes. It also addresses the incubation periods, pathogenicity and clinical findings associated with each pathogen and genospecies and presents case examples. Current data on prevalence, annual fluctuations and distribution in various pre-selected dog populations (symptomatic versus asymptomatic) in both countries are depicted in maps. Reasons for changes in prevalence (especially of Borrelia) are discussed. Criteria and algorithms for clinical diagnosis and monitoring in dogs, including case history, direct detection (blood smears, molecular detection by species-specific PCR and sequencing) and indirect methods (whole-cell and peptide-based antibody tests), are presented, together with laboratory abnormalities (haematology, clinical chemistry, urine). The role of anti-C6 antibody concentration (ACAC) and its correlation with proteinuria and Lyme nephritis are assessed on the basis of new data. Consideration is also given to the importance of blood smears, PCR and serology in the case of anaplasmosis and babesiosis, and the diagnostic value of combining these methods. The relevance of molecular differentiation of Anaplasma species (A. phagocytophilum versus A. platys) and Babesia spp. (large versus small forms) in cases of serological cross-reaction is emphasized. A summary is given of methods for prophylaxis using acaricide products (collars, spot-on solutions and oral treatments in both countries), vaccination (Borrelia and Babesia vaccines) and imidocarb-based chemoprophylaxis for large Babesia.

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Section: S31mentioning

confidence: 97%

Section: S44mentioning

confidence: 98%

Section: S31mentioning

confidence: 99%

mentioning

confidence: 99%

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Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis

et al. 2015

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“…No experimental model to study its pathogenesis, treatment, and prevention in over‐represented (retriever) breeds has been developed, and no validated staining techniques are available to prove that glomerular immune‐complexes are Lyme‐specific in kidney biopsy specimens from living dogs. Despite these limitations, strategies for empirical management of Lyme nephritis are given, as recently offered by the International Renal Interest Society (IRIS) Glomerular Disease Study Group …”

Section: Introductionmentioning

confidence: 99%

ACVIM consensus update on Lyme borreliosis in dogs and cats

Littman

Gerber

Goldstein

et al. 2018

Veterinary Internal Medicne

118

149

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An update of the 2006 American College of Veterinary Internal Medicine (ACVIM) Small Animal Consensus Statement on Lyme Disease in Dogs: Diagnosis, Treatment, and Prevention was presented at the 2016 ACVIM Forum in Denver, CO, followed by panel and audience discussion and a drafted consensus statement distributed online to diplomates for comment. The updated consensus statement is presented below. The consensus statement aims to provide guidance on the diagnosis, treatment, and prevention of Lyme borreliosis in dogs and cats.

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Lyme Nephritis

Littman

2018

Textbook of Small Animal Emergency Medicine

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Consensus Recommendations for Treatment for Dogs with Serology Positive Glomerular Disease

Cited by 27 publications

References 21 publications

Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis

Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis

ACVIM consensus update on Lyme borreliosis in dogs and cats

Lyme Nephritis

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