Consensus Guidelines from The American Society of Peritoneal Surface Malignancies on Standardizing the Delivery of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Patients in the United States

Abstract

This recommendation on a standardized delivery of HIPEC in patients with colorectal cancer represents an important first step in enhancing research in this field. Studies directed at maximizing the efficacy of each of the seven key elements will need to follow.

S3-Leitlinie – Kolorektales Karzinom

“…Die Durchführung einer HIPEC-Therapie ist aufgrund der damit verbundenen Morbidität an ausgewiesene "high-volume"-Zentren gebunden [1214]. Die Effektivität der zytoreduktiven Chirurgie ist insbesondere vom Ausmaß der Peritonealkarzinose abhän-gig.…”

Incidence and treatment of recurrent disease after cytoreductive surgery and intraperitoneal chemotherapy for peritoneally metastasized colorectal cancer: A systematic review

“…Therefore, after resection of macroscopic disease e commonly referred to as cytoreductive surgery or CRS e intraperitoneal chemotherapy (IPC) is administered in high dosages to destroy remaining tumor cells. 1,2 The addition of heat (HIPEC) is thought to further enhance the effect of IPC. 3 In the last two decades, this treatment has evolved and in selected patients a 5-year survival rate of up to 40% has been reported.…”

Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?

“…It should be noted that surgery combined with HIPEC is invasive and time consuming. Also, standardized treatment protocols regarding drug schedule and dose, perfusion temperature, and perfusion duration are currently unavailable [28]. Thereafter, the capnoperitoneum is deflated through a closed suction system.…”