2013
DOI: 10.1038/nature12346
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Connectomic reconstruction of the inner plexiform layer in the mouse retina

Abstract: Comprehensive high-resolution structural maps are central to functional exploration and understanding in biology. For the nervous system, in which high resolution and large spatial extent are both needed, such maps are scarce as they challenge data acquisition and analysis capabilities. Here we present for the mouse inner plexiform layer--the main computational neuropil region in the mammalian retina--the dense reconstruction of 950 neurons and their mutual contacts. This was achieved by applying a combination… Show more

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Cited by 964 publications
(1,206 citation statements)
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“…Helmstaedter and Winfried Denk -director of the Max Planck Institute for Neurobiology in Martinsried -have published the largest microconnectome reported so far: a cube of mouse retina measuring 100 micrometres to a side and encompassing about 1,000 neurons and 250,000 synapses 5 . That was about twomillionths of the mouse brain.…”
Section: Zooming Inmentioning
confidence: 99%
“…Helmstaedter and Winfried Denk -director of the Max Planck Institute for Neurobiology in Martinsried -have published the largest microconnectome reported so far: a cube of mouse retina measuring 100 micrometres to a side and encompassing about 1,000 neurons and 250,000 synapses 5 . That was about twomillionths of the mouse brain.…”
Section: Zooming Inmentioning
confidence: 99%
“…When the data is high dimensional data or structure is very complex, deep learning has been proved very effective in dealing with the data, so it is applied in many fields, such as science, enterprise, government and so on. In addition to the image recognition [10][11][12] and speech recognition [13][14][15] to beat other machine learning techniques, in the prediction of potential drug molecules [16], analysis of particle accelerator data and the reconstruction of brain circuits [17], the deep learning method has also defeated other machine learning techniques. Perhaps more surprising is that in some important subjects of natural language understanding, particularly theme classification, sentiment analysis, question-answering system and machine translation, deep learning method also brings encouraging results.…”
Section: The Development Of Deep Learningmentioning
confidence: 99%
“…33,34 For certain tasks, human creativity and judgment can outperform automated classication and search algorithms. Recent years have seen exciting mergers between interactive molecular simulation and ideas within crowdsourced human-computer interaction.…”
Section: Introductionmentioning
confidence: 99%