Connectivity Profiles Reveal a Transition Subarea in the Parahippocampal Region That Integrates the Anterior Temporal–Posterior Medial Systems

Zhuo, Junjie; Fan, Lingzhong; Liu, Yong; Zhang, Yuanchao; Yu, Chunshui; Jiang, Tianzi

doi:10.1523/jneurosci.1975-15.2016

Cited by 36 publications

(39 citation statements)

References 60 publications

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“…In these studies, as in our findings, the most anterior aspect of the MTL cortex responded to object stimuli, whereas the middle transitional zone of the cortex responded to both object and scene information. This transitional zone between PRC and PHC has also recently been found to have unique functional and anatomical characteristics in relation to the more anterior or posterior portions of the parahippocampal gyrus (Zhuo et al, ). Nevertheless, contrary to the selective response to scene stimuli in the posterior MTL cortex in previous studies (Litman et al, ; Staresina et al, ), our findings show that even in the posterior aspect of the gyrus (and indeed even in the posterior PHC), the activation patterns were sensitive to both object and scene familiarity.…”

Section: Discussionmentioning

confidence: 97%

Material Specificity Drives Medial Temporal Lobe Familiarity But Not Hippocampal Recollection

et al. 2016

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The specific role of the perirhinal (PRC), entorhinal (ERC) and parahippocampal cortices (PHC) in supporting familiarity‐based recognition remains unknown. An fMRI study explored whether these medial temporal lobe (MTL) structures responded in the same way or differentially to familiarity as a function of stimulus type at recognition. A secondary aim was to explore whether the hippocampus responds in the same way to equally strong familiarity and recollection and whether this is influenced by the kind of stimulus involved. Univariate and multivariate analyses revealed that familiarity responses in the PRC, ERC, PHC and the amygdala are material‐specific. Specifically, the PRC and ERC selectively responded to object familiarity, while the PHC responded to both object and scene familiarity. The amygdala only responded to familiarity memory for faces. The hippocampus did not respond to stimulus familiarity for any of the three types of stimuli, but it did respond to recollection for all three types of stimuli. This was true even when recollection was contrasted to equally accurate familiarity. Overall, the findings suggest that the role of the MTL neocortices and the amygdala in familiarity‐based recognition depends on the kind of stimulus in memory, whereas the role of the hippocampus in recollection is independent of the type of cuing stimulus. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 97%

Material Specificity Drives Medial Temporal Lobe Familiarity But Not Hippocampal Recollection

et al. 2016

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“…While atrophy is relatively homogeneous along the hippocampus in AD [Davies et al, ; Jack et al, ], it strongly predominates in the head of the hippocampus in SD [La Joie et al, ; Tan et al, ]. Interestingly, several studies have highlighted that the connectivity of hippocampus [Aggleton, ; Poppenk et al, ] but also entorhinal [Maass et al, ; Navarro Schröder et al, ] and perirhinal [Zhuo et al, ] cortices varies along the anterior–posterior axis. It is thus possible that the earliest MTL lesions occur in distinct regions in AD versus SD and that the pathology then spreads across distinct sub‐MTL networks.…”

Section: Discussionmentioning

confidence: 99%

Distinct white matter injury associated with medial temporal lobe atrophy in Alzheimer's versus semantic dementia

Bejanin

Desgranges

Joie

et al. 2016

Human Brain Mapping

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This study aims at further understanding the distinct vulnerability of brain networks in Alzheimer's disease (AD) versus semantic dementia (SD) investigating the white matter injury associated with medial temporal lobe (MTL) atrophy in both conditions. Twenty-six AD patients, twenty-one SD patients, and thirty-nine controls underwent a high-resolution T1-MRI scan allowing to obtain maps of grey matter volume and white matter density. A statistical conjunction approach was used to identify MTL regions showing grey matter atrophy in both patient groups. The relationship between this common grey matter atrophy and white matter density maps was then assessed within each patient group. Patterns of grey matter atrophy were distinct in AD and SD but included a common region in the MTL, encompassing the hippocampus and amygdala. This common atrophy was associated with alterations in different white matter areas in AD versus SD, mainly including the cingulum and corpus callosum in AD, while restricted to the temporal lobe - essentially the uncinate and inferior longitudinal fasciculi - in SD. Complementary analyses revealed that these relationships remained significant when controlling for global atrophy or disease severity. Overall, this study provides the first evidence that atrophy of the same MTL region is related to damage in distinct white matter fibers in AD and SD. These different patterns emphasize the vulnerability of distinct brain networks related to the MTL in these two disorders, which might underlie the discrepancy in their symptoms. These results further suggest differences between AD and SD in the neuropathological processes occurring in the MTL. Hum Brain Mapp 38:1791-1800, 2017. © 2017 Wiley Periodicals, Inc.

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“…There was no significant laterality effect in the PM (t(37) = .29, P = . 77) and MP subnetworks (t(37) = .98, P = .33). This connectivity difference might help to explain differentiated function of the left and right hippocampus.…”

Section: Cortico-hippocampal Network Connectivitymentioning

confidence: 99%

Organization of cortico-hippocampal networks in the human brain

Barnett

Reilly

Dimsdale-Zucker

et al. 2020

Preprint

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Episodic memory is thought to depend on interactions between the hippocampus and a set of closely interconnected regions that comprise the default mode network (DMN)-a large-scale network that has been identified with resting-state fMRI. Here, using data-driven analyses of resting-state fMRI data to characterize cortico-hippocampal network connectivity, we identified a discrete set of subnetworks that interact with the hippocampus. Specifically, we found that the hippocampus closely affiliated with the DMN and with a "Medial Temporal Network" (MTN) that included regions in the medial temporal lobe and retrosplenial cortex. The DMN could be further subdivided into three subnetworks: a "Posterior Medial" Subnetwork comprised of regions in the posterior cingulate, lateral parietal, and dorsal prefrontal cortex, an "Anterior Temporal" Subnetwork comprised of regions in the temporopolar, lateral orbitofrontal, and dorsal medial prefrontal cortex, and a "Medial Prefrontal" Subnetwork comprised of regions in the ventral medial prefrontal, and entorhinal cortex. These cortico-hippocampal networks vary in their functional connectivity along the hippocampal long-axis, and analyses of an independent task-fMRI dataset revealed that the three DMN subnetworks represent different kinds of information during memory-guided decision-making. Finally, a data-driven meta-analysis of functional imaging studies of cognition suggests new hypotheses regarding the functions of the MTN and DMN subnetworks, thus providing a framework to guide future research on the neural architecture of episodic memory. Significance StatementNetwork neuroscience has identified large-scale networks across the human brain, but this literature focuses almost exclusively on cortical regions, with sparse characterization of subcortical regions like the hippocampus. The hippocampus is critical for encoding and retrieving episodic memories, but it is currently unclear how the hippocampus interacts with distributed networks in the brain. Here, we used network neuroscience techniques to identify and characterize cortico-hippocampal networks. We find that these cortico-hippocampal networks can be differentiated on the basis of functional connectivity along the hippocampal long-axis, information represented in an independent task-fMRI dataset, and in a meta-analysis of task fMRI studies. Our work demonstrates that the functional organization of memory processes may be determined by the network topology of the human brain.Episodic memory allows us to relive past events that happened at a particular place and time (1). Most research investigating the neurobiology of episodic memory retrieval has focused on the hippocampus and medial temporal lobe (MTL) cortex (perirhinal, parahippocampal, and entorhinal cortex) highlighting the interactions among these regions (2-4). It is generally assumed, however, that the hippocampus supports memory by integrating information represented across distributed areas in the neocortex (5). Consistent with this idea, fMRI studies of memor...

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Connectivity Profiles Reveal a Transition Subarea in the Parahippocampal Region That Integrates the Anterior Temporal–Posterior Medial Systems

Cited by 36 publications

References 60 publications

Material Specificity Drives Medial Temporal Lobe Familiarity But Not Hippocampal Recollection

Material Specificity Drives Medial Temporal Lobe Familiarity But Not Hippocampal Recollection

Distinct white matter injury associated with medial temporal lobe atrophy in Alzheimer's versus semantic dementia

Organization of cortico-hippocampal networks in the human brain

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