Connective tissue alteration in abdominal wall hernia

Henriksen, Nadia A; Yadete, D. H.; Sørensen, Lars Tue; Ågren, Magnus S.; Jørgensen, Lars N.

doi:10.1002/bjs.7339

Cited by 131 publications

(86 citation statements)

References 81 publications

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“…Maybe mechanical exposures can also act through a mechanism involving gradual degradation and weakening of the transversalis fascia (61,(69)(70)(71) leading to accelerated age-induced degeneration [cf, the increasing ratio of medial to lateral hernias with age (7)]. In accordance with this, connective tissue alterations have been reported to be more pronounced in patients with a medial inguinal hernia than those with a lateral inguinal hernia (72). Hernia formation has been related to increased elasticity of the transversalis fascia (73) and weak collagen structure and/or defects in collagen (74)(75)(76) and elastic fibre (77) metabolism.…”

Section: Contributory Evidence With Respect To Risk Of Hernia Formationsupporting

confidence: 64%

Risk and prognosis of inguinal hernia in relation to occupational mechanical exposures - a systematic review of the epidemiologic evidence

Svendsen¹,

Frost²,

Vad³

et al. 2012

Scand J Work Environ Health

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Risk and prognosis of inguinal hernia in relation to occupational mechanical exposures -a systematic review of the epidemiologic evidence by Svendsen SW, Frost P, Vad MV, Andersen JH -One in four men undergoes inguinal hernia repair that carries a risk of recurrence and persistent pain. -Occupational mechanical exposures may increase the risk of occurrence and of an unfavourable prognosis. -The epidemiologic evidence is too limited to draw conclusions for or against any causal or prognostic associations. -There is a need for new knowledge with an emphasis on prevention. Scand J Work Environ Health. 2013;39(1):5-26. doi:10.5271/sjweh.3305 Risk and prognosis of inguinal hernia in relation to occupational mechanical exposures -a systematic review of the epidemiologic evidence Objectives The aim of this review was to evaluate the epidemiologic evidence for (i) a causal effect of occupational mechanical exposures on incidence of inguinal hernia, and (ii) a prognostic effect of such exposures on hernia recurrence and persistent pain after inguinal hernia repair. Affiliation MethodsWe performed a literature search in Medline, Embase, and Web of Science up to 3 November 2011.Central information was extracted from included studies, and strengths and limitations were discussed. ResultsAll 23 included studies focused on effects of (work) activities that hardly reflected specific occupational risk factors. Eight studies provided information on risk by occupation or occupational activities. Increased risk was reported in six studies, but inflationary bias was likely. The negative findings in two studies might well be explained by bias towards the null due to crude exposure and/or outcome assessment. Three studies on single strenuous events primarily reflected patients' beliefs regarding risk factors. Information on prognosis with respect to recurrence was found in seven studies. The studies used crude exposure assessment, and two were also underpowered. Four suggested an increased risk. Six studies on prognosis with respect to persistent pain (one of which also concerned recurrence) were practically non-informative for the purpose of this review. ConclusionsThere is insufficient epidemiologic evidence to draw meaningful conclusions about (i) the existence of causal associations between specific occupational mechanical exposures and the development of inguinal hernia, and (ii) the influence of these exposures on prognosis after inguinal hernia repair with respect to hernia recurrence and persistent pain.

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Section: Contributory Evidence With Respect To Risk Of Hernia Formationsupporting

confidence: 64%

Risk and prognosis of inguinal hernia in relation to occupational mechanical exposures - a systematic review of the epidemiologic evidence

Svendsen¹,

Frost²,

Vad³

et al. 2012

Scand J Work Environ Health

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“…These neutrophils secrete potent tissue-destructive enzymes, such as collagenases and elastase. These processes make the collagen in the abdominal wall thinner and thus weaken the abdominal wall [1,17,26]. Despite this, currently there is no evidence suggesting that smoking is directly associated with a first epigastric herniation.…”

Section: Factors Associated With Epigastric Herniationmentioning

confidence: 99%

Pathogenesis of the epigastric hernia

Ponten

Somers

Nienhuijs

2012

Hernia

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“…11 There is strong evidence that collagen imbalance contributes to the pathogenesis of hernias. 12 Changes in collagen metabolism may lead to weakened fascia, which plays an essential role in the support of the pelvic viscera. 13 For an overview of the ligamentous layers in the pelvis, see Figure 1, which describes the three imaginary planes, based on the level of support.…”

Section: Introductionmentioning

confidence: 99%

Recent studies of genetic dysfunction in pelvic organ prolapse: The role of collagen defects

Lim

Khoo

Wong

et al. 2014

Aust NZ J Obst Gynaeco

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Gynaecologists are becoming increasingly aware that women with a family history of prolapse are at an increased risk of prolapse refractory to treatment. In the past five years, several genetic mutations have been shown to correlate with increased prolapse susceptibility. These mutations can result in disordered collagen metabolism, which weaken the fascial support of the pelvic organs. This review examines the contemporary evidence regarding the role of collagen in prolapse.

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Connective tissue alteration in abdominal wall hernia

Abstract: Hernia formation and recurrence is associated with altered collagen metabolism manifested by a decreased type I:III collagen ratio.

Cited by 131 publications

References 81 publications

Risk and prognosis of inguinal hernia in relation to occupational mechanical exposures - a systematic review of the epidemiologic evidence

Risk and prognosis of inguinal hernia in relation to occupational mechanical exposures - a systematic review of the epidemiologic evidence

Pathogenesis of the epigastric hernia

Recent studies of genetic dysfunction in pelvic organ prolapse: The role of collagen defects

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