Connections of the retrosplenial granular a cortex in the rat

Groen, Thomas van; Wyss, J. Michael

doi:10.1002/cne.903000412

Cited by 324 publications

(276 citation statements)

References 52 publications

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“…Other major cortical projections of the RSPagl extend caudally and medially to pre-and parasubicular areas of the hippocampal formation and to other parts of the RSP that also project to the hippocampal formation (27). Note that in Fig.…”

Section: Discussionmentioning

confidence: 91%

Evidence for a hypothalamothalamocortical circuit mediating pheromonal influences on eye and head movements.

Risold

Swanson

1995

Proc. Natl. Acad. Sci. U.S.A.

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A method for simultaneous iontophoretic injections of the anterograde tracer Phaseolus vulgaris leukoagglutinin and the retrograde tracer fluorogold was used to characterize in the rat a hypothalamothalamocortical pathway ending in a region thought to regulate attentional mechanisms by way of eye and head movements. The relevant medial hypothalamic nuclei receive pheromonal information from the amygdala and project to specific parts of the thalamic nucleus reuniens and anteromedial nucleus, which then project to a specific lateral part of the retrosplenial area (or medial visual cortex). This cortical area receives a convergent input from the lateral posterior thalamic nucleus and projects to the superior colliculus. Bidirectional connections with the hippocampal formation suggest that activity in this circuit is modified by previous experience. Striking parallels with basal ganglia circuitry are noted.The organization of circuits that mediate orienting responses to somatosensory, visual, and auditory stimuli is known at least in outline, with important components including the thalamus, motor cortical areas, and superior colliculus (1, 2). In contrast, almost nothing is understood about how pheromonal and other olfactory stimuli, which in rodents are particularly important for reproductive, aggressive, and ingestive behaviors, influence eye and head movements. Pheromonal information is relayed by sexually dimorphic pathways involving the vomeronasal organ, accessory olfactory bulb, and corticomedial amygdala to the medial zone of the hypothalamus, but there is little evidence for projections from this circuitry to thalamic, cortical, and midbrain regions concerned directly with regulating eye and head movements and, thus, visuomotor and directed attentional mechanisms (3, 4).We have recently identified dense projections from three adjacent, highly interconnected medial hypothalamic nuclei (anterior, ventromedial, and dorsal premammillary) to two adjacent nuclei of the rostral thalamus, the rostral nucleus reuniens (REr) and ventral anteromedial nucleus (AMv) (5-7). In the work presented here, a method for simultaneous injection into the same site of the anterograde axonal tracer Phaseolus vulgaris leukoagglutinin (PHAL) and the retrograde axonal tracer fluorogold (FG) was used to characterize the hypothalamic and cortical interconnections of the REr. At the cortical level, the method was used to define the connections of a very restricted area that receives a convergent input from the REr and lateral posterior thalamic nucleus (LP) and that projects back to the LP and superior colliculus. On cytoarchitectonic grounds, this cortical area has previously been regarded as either the lateralmost part of the retrosplenial area (RSP) or the medialmost part of the visual cortex in the rat or mouse (for example, see refs. 8 and 9).The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 sole...

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Section: Discussionmentioning

confidence: 91%

Evidence for a hypothalamothalamocortical circuit mediating pheromonal influences on eye and head movements.

Risold

Swanson

1995

Proc. Natl. Acad. Sci. U.S.A.

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“…86). In non-human primates, retrosplenial and adjacent posterior cingulate cortex project further to PPC (77,87), although it is uncertain whether such direct retrosplenial-parietal connections exist in the rat (82,83,88), but see refs. 76 and 89).…”

Section: Output Pathways From Medial Entorhinal To Posterior Parietalmentioning

confidence: 99%

Navigating from hippocampus to parietal cortex

Whitlock

Sutherland

Witter

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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187

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The navigational system of the mammalian cortex comprises a number of interacting brain regions. Grid cells in the medial entorhinal cortex and place cells in the hippocampus are thought to participate in the formation of a dynamic representation of the animal's current location, and these cells are presumably critical for storing the representation in memory. To traverse the environment, animals must be able to translate coordinate information from spatial maps in the entorhinal cortex and hippocampus into bodycentered representations that can be used to direct locomotion. How this is done remains an enigma. We propose that the posterior parietal cortex is critical for this transformation.entorhinal cortex ͉ grid cell ͉ place cell ͉ Path integration ͉ spatial memory

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“…Research into the functions of the retrosplenial cortex has often considered its potential roles in spatial memory ), reflecting its dense interconnections with the hippocampus and anterior thalamic nuclei (Van Groen and Wyss 1990. However, other connections of the rodent retrosplenial cortex suggest a broader role in multimodal processing.…”

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confidence: 99%

Dysgranular retrosplenial cortex lesions in rats disrupt cross-modal object recognition

et al. 2014

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The retrosplenial cortex supports navigation, with one role thought to be the integration of different spatial cue types. This hypothesis was extended by examining the integration of nonspatial cues. Rats with lesions in either the dysgranular subregion of retrosplenial cortex (area 30) or lesions in both the granular and dysgranular subregions (areas 29 and 30) were tested on cross-modal object recognition (Experiment 1). In these tests, rats used different sensory modalities when exploring and subsequently recognizing the same test objects. The objects were first presented either in the dark, i.e., giving tactile and olfactory cues, or in the light behind a clear Perspex barrier, i.e., giving visual cues. Animals were then tested with either constant combinations of sample and test conditions (light to light, dark to dark), or changed "cross-modal" combinations (light to dark, dark to light). In Experiment 2, visual object recognition was tested without Perspex barriers, but using objects that could not be distinguished in the dark. The dysgranular retrosplenial cortex lesions selectively impaired cross-modal recognition when cue conditions switched from dark to light between initial sampling and subsequent object recognition, but no impairment was seen when the cue conditions remained constant, whether dark or light. The combined (areas 29 and 30) lesioned rats also failed the dark to light cross-modal problem but this impairment was less selective. The present findings suggest a role for the dysgranular retrosplenial cortex in mediating the integration of information across multiple cue types, a role that potentially applies to both spatial and nonspatial domains.

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Connections of the retrosplenial granular a cortex in the rat

Cited by 324 publications

References 52 publications

Evidence for a hypothalamothalamocortical circuit mediating pheromonal influences on eye and head movements.

Evidence for a hypothalamothalamocortical circuit mediating pheromonal influences on eye and head movements.

Navigating from hippocampus to parietal cortex

Dysgranular retrosplenial cortex lesions in rats disrupt cross-modal object recognition

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