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Cited by 31 publications
(20 citation statements)
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References 26 publications
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“…73 Confocal studies and infrared meibography revealed severe inflammation and extensive fibrosis in cGVHD-related dry eye recipients in comparison with the conditions in the non-GVHD group. 90,91 The mean fibrosis grade was significantly higher in the DE/cGVHD group than in the non-DE/non-cGVHD group (P < 0.0001; 1.39 6 0.71 grade, 0.06 6 0.25 grade, respectively). 90 However, we need to examine MGD in the early stages before and after HSCT 92 because various types of MGD are already present before HSCT.…”
Section: Chronic Graft-versus-host Disease-related Dry Eyementioning
confidence: 88%
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“…73 Confocal studies and infrared meibography revealed severe inflammation and extensive fibrosis in cGVHD-related dry eye recipients in comparison with the conditions in the non-GVHD group. 90,91 The mean fibrosis grade was significantly higher in the DE/cGVHD group than in the non-DE/non-cGVHD group (P < 0.0001; 1.39 6 0.71 grade, 0.06 6 0.25 grade, respectively). 90 However, we need to examine MGD in the early stages before and after HSCT 92 because various types of MGD are already present before HSCT.…”
Section: Chronic Graft-versus-host Disease-related Dry Eyementioning
confidence: 88%
“…96 One study showed only a weakly positive correlation with subepithelial fibrosis and severe dry eye measured by using ICOS, although there is no significant correlation among subepithelial fibrosis, meibomian gland atrophy, and ICOS. 91 Two major review articles 62,97 cited the International Consensus Diagnostic Criteria and evaluated the consensus scores. 65 As for GVHD-related dry eye (but not common dry eye), it is better to evaluate ocular surface staining and the value of Schirmer's test to determine the severity of dry eye and the disease process.…”
Section: Chronic Graft-versus-host Disease-related Dry Eyementioning
confidence: 99%
“…Patients with ocular graft-versus-host disease were found to show a significant loss of meibomian glands compared with control individuals, suggesting that gland abnormalities may be a cause of dry eye in such patients. 59,60 Further research is required to help elucidate the role of acute versus chronic inflammation in driving the meibomian gland changes observed in graft-versus-host-disease.…”
Section: Ocular Graft-versus-host Diseasementioning
confidence: 99%
“…The main histologic findings in the affected ocular surface are marked fibrosis of the subepithelial interstitium [15,16], prominent increase in the number of CD34 + fibroblasts in the lacrimal glands, and lymphocytic infiltration of the lacrimal glands [14]. T cells are detected mainly in the periductal area, with some T cells infiltrating into ductal epithelia through disrupted laminae in lacrimal glands.…”
Section: Pathophysiologymentioning
confidence: 99%
“…As reviewed herein, preclinical models have also implicated inflammation, immune dysregulation, and fibrosis in ocular GVHD [15,17,23,24,26]. Novel agents that target specific pathways of chronic GVHD are currently under investigation, including Janus kinase inhibitors, Bruton's tyrosine kinase inhibitors, and Rho kinase inhibitors.…”
Section: Summary and Recommendations For Future Researchmentioning
confidence: 99%