Conjunctiva is not a preferred gateway of entry for SARS‐CoV‐2 to infect respiratory tract

Abstract

1 1 case positive Days 3 and 5 (sampled twice for the same patient) Abbreviations: CoV, coronavirus; NA, not available; RNA, ribonucleic acid; SARS-CoV, severe acute respiratory syndrome coronavirus. |LETTER TO THE EDITOR SARS-CoV-2 infection is transmitted via the nose and throat route than via the conjunctiva route in this animal model. SARS-CoV-2 exposed to the ocular surface might first be transported to nasal and nasopharyngeal mucosa by constant tear rinsing through lacrimal duct, and then cause respiratory tract infection. Similar findings were reported in a cynomolgus macaques model using conjunctival and nasal inoculation with SARS-CoV virus. 2

COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic

“…Therefore, it is currently unclear if sole ocular contact with SARS-CoV 2 can manifest in an infection [17]. Based on the current literature, exposure of the ocular surface to SARS-CoV 2 might confer infection most probably due to drainage of virus particles via the nasolacrimal duct into the respiratory tract [21,22]. Therefore, the use of protective glasses or shields is recommended [23 -25].…”

Conjunctivitis and COVID‐19: A meta‐analysis

“…3 However, the role of conjunctiva in COVID-19 still remains unclear. 8,9 The results of this study could have important clinical implications. First, medical doctors have to recognize conjunctivitis as a possible sign of COVID-19 associated to a severe form of disease.…”

Modifications of emergency dental clinic protocols to combat COVID‐19 transmission

“…Clinically acceptable PPE includes disposable booties, full length gown, head cover, gloves that overlap the sleeves of the gown, N95 respirator, surgical mask, and face shield. Goggles are not currently required as the conjunctiva is not a preferred gateway for SARS‐CoV‐2 to infect the respiratory system 47 . Providers are required to wear primary masks rated N95 or greater as conventionally used Level 1 surgical masks do not provide adequate aerosol particle protection.…”