Conidiobolus coronatus infection treated with ketoconazole

Towersey, L.

doi:10.1001/archderm.124.9.1392

Cited by 13 publications

(19 citation statements)

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“…miconazole has been tried in one case without success (13). Ketoconazole and itraconazole have been successfully tried in some cases in Congo (4), Central African Republic (49) and Brazil (51). Failure of ketoconazole therapy, despite the in vitro sensitivity to C. coronatus, has been reported in a few patients (13).…”

Section: Treatmentmentioning

confidence: 99%

Entomophthoromycosis due to Conidiobolus

Gugnani

1992

Eur J Epidemiol

101

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Entomophthoromycosis due to Conidiobolus coronatus is a granulomatous infection characterized by lesions that originate in the inferior turbinate, spread through ostia and foramina to involve the facial and subcutaneous tissues and paranasal sinuses. The majority of the cases have been described from areas of tropical rainforest in West Africa, agricultural and outdoor workers (aged 20-60 years) being the ones most frequently affected. The fungus is common in soil and decaying vegetation. Infection probably occurs by implantation of the spores of the fungus in nasal mucosa. C. incongruus is a rare agent of the disease, so far known only from two cases with lesions involving the pericardium, mediastinum, lungs, liver, oesophagus and jejunum. C. coronatus is known to cause a clinically similar disease in horses, mules, a dolphin and a chimpanzee. A characteristic histological feature is the presence of thin-walled, broad, often septate hyphae or hyphal fragments with a thick eosinophilic sheath, frequently phagocytosed within giant cells. The fungus is known to produce in vitro several enzymes, e.g., elastase, esterase, collagenase and lipase, which have a possible role in pathogenicity. A concentrated brain heart infusion culture filtrate antigen is useful for immunodiagnosis. Several drugs e.g., potassium iodide, cotrimoxazole, amphotericin B, ketoconazole and itraconazole have been tried with varying success. Investigations on the immunology of disease and the role of proteases and lipases in the pathogenesis of infection is an important area of further research.

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Section: Treatmentmentioning

confidence: 99%

Entomophthoromycosis due to Conidiobolus

Gugnani

1992

Eur J Epidemiol

101

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“…9 There is no definitive therapy for Conidiobolus infections, although trimethoprim-sulfamethoxazole, potassium iodide, amphotericin B, and some of the azoles (itraconazole, fluconazole and ketoconazole) have shown limited efficacy. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Clinical failure has been reported with all.…”

Section: Discussionmentioning

confidence: 99%

Periorbital Cellulitis Secondary to Conidiobolus incongruus

et al. 2001

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A previously healthy, 18-month-old girl developed edema and erythema around her left eye 1 week after getting sand in that eye. The patient did not respond to oral or intravenous antibiotics. A mass developed around the eye, and biopsy revealed Conidiobolus incongruus. The patient failed to respond to amphotericin B 1 mg/kg, and susceptibility tests indicated multiantifungal resistance. A combination of antifungal therapy, hyperbaric oxygen, and surgery was required for successful treatment. Three months after treatment the child was disease free. There is no definitive therapy for Conidiobolus incongruus infections, although various drugs have been administered with some success. When susceptibility tests determine multidrug resistance, radical resection with antifungal chemotherapy and hyperbaric oxygen may be necessary as well as lifesaving.

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“…Different azoles, amphotericin B, and flucytosine have been shown to be effective in vitro [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], and a number of azoles as well as amphotericin B, potassium iodide, and sulfamethoxazole plus trimethoprime have been described to have a beneficial clinical effect in some patients [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Rhinofacial Conidiobolus coronatus Infection Presenting with Nasal Enlargement

et al. 2008

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Rhinofacial Conidiobolus coronatus infection is a rare form of zygomycosis in humans living in the northern hemispheres. Most human cases are observed in the periequatorial areas of Africa, Asia, or South America. Only limited information regarding optimal treatment is available. We report a case of rhinofacial C. coronatus infection in an emigrated Sudanese patient. The infection was successfully treated with terbinafin and itraconazole for 12 months. Diagnosis was confirmed by microbiological culture from a tissue biopsy. Antimicrobial susceptibility testing of this organism was not predictive of optimal therapy.

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Conidiobolus coronatus infection treated with ketoconazole

Cited by 13 publications

References 0 publications

Entomophthoromycosis due to Conidiobolus

Entomophthoromycosis due to Conidiobolus

Periorbital Cellulitis Secondary to Conidiobolus incongruus

Rhinofacial Conidiobolus coronatus Infection Presenting with Nasal Enlargement

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