Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation

França, Giovanny Vinícius Araújo de; Schüler‐Faccini, Lavínia; Oliveira, Wanderson Kleber de; Henriques, Cláudio Maierovitch Pessanha; Carmo, Eduardo Hage; Pedi, Vaneide Daciane; Nunes, Marília Lavocat; Castro, Márcia C.; Serruya, Suzanne Jacob; Silveira, Mariângela Freitas da; Barros, Fernando C.; Victora, Cesar G

doi:10.1016/s0140-6736(16)30902-3

Cited by 531 publications

(573 citation statements)

References 19 publications

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“…There is a well-defined time lag between the epidemic curve and this birth curve. Brazil, which likely experienced its first ZIKV epidemic peak in March 2015, had a sharp rise in microcephaly cases in September 2015, consistent with what was observed in the field (40). In Colombia 132 confirmed cases of congenital Zika syndrome had been observed as of March 11, 2017 (56).…”

Section: Projected Zikv Infections In Childbearing Women and Microcepmentioning

confidence: 53%

Spread of Zika virus in the Americas

Zhang

Sun

Chinazzi

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

281

309

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We use a data-driven global stochastic epidemic model to analyze the spread of the Zika virus (ZIKV) in the Americas. The model has high spatial and temporal resolution and integrates real-world demographic, human mobility, socioeconomic, temperature, and vector density data. We estimate that the first introduction of ZIKV to Brazil likely occurred between August 2013 and April 2014 (90% credible interval). We provide simulated epidemic profiles of incident ZIKV infections for several countries in the Americas through February 2017. The ZIKV epidemic is characterized by slow growth and high spatial and seasonal heterogeneity, attributable to the dynamics of the mosquito vector and to the characteristics and mobility of the human populations. We project the expected timing and number of pregnancies infected with ZIKV during the first trimester and provide estimates of microcephaly cases assuming different levels of risk as reported in empirical retrospective studies. Our approach represents a modeling effort aimed at understanding the potential magnitude and timing of the ZIKV epidemic and it can be potentially used as a template for the analysis of future mosquito-borne epidemics. Using a data-driven stochastic and spatial epidemic model, we present numerical results providing insight into the first introduction in the region and the epidemic dynamics across the Americas. We use the model to analyze the spatiotemporal spread and magnitude of the epidemic in the Americas through to February 2017, accounting for seasonal environmental factors and detailed population data. We also provide projections of the number of pregnancies infected with ZIKV during the first trimester, along with estimates for the number of microcephaly cases per country using three different levels of risk based on empirical retrospective studies (36, 37). ResultsIntroduction of ZIKV to the Americas. We identify 12 major transportation hubs in areas related to major events held in Brazil,

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Section: Projected Zikv Infections In Childbearing Women and Microcepmentioning

confidence: 53%

Spread of Zika virus in the Americas

Zhang

Sun

Chinazzi

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

281

309

View full text Add to dashboard Cite

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“…Microcephaly seems to depend on the timing of prenatal ZIKV infection, with infections early in pregnancy i.e., in the first and early second trimesters being mostly associated with microcephaly. Fetal microcephaly is most likely due to increased developmental neuronal apoptosis secondary to early ZIKV infection of progenitor cells [17][18][19][20][21][22]. The risk of ZIKV infection associated fetal microcephaly is estimated to be 95 (95 CI 34-191) per 10,000 pregnant women that are infected in the first trimester of pregnancy [17].…”

Section: Fetal Brain Ultrasoundmentioning

confidence: 99%

“…Other fetal ultrasound findings include: (1) unilateral or bilateral ventriculomegaly which may be associated with subependymal pseudocysts around the occipital horns; (2) brain parenchymal atrophy and calcifications; (3) agenesis/ hypoplasia of the corpus callosum with or without interhemispheric cyst; (4) absent cavum septum pellucidum; (5) global cerebellar or vermian hypoplasia; (6) medullary and pontine hypoplasia; (7) ocular abnormalities, like microphthalmia, intraocular calcification, and cataract [17][18][19][20][21][22].…”

Section: Fetal Brain Ultrasoundmentioning

confidence: 99%

Neuroimaging findings of Zika virus infection: a review article

et al. 2016

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“…Among the infectious agents, Zika virus infection is one of the latest epidemiologic highlights and has been associated with a large number of microcephaly cases in Brazil, particularly between 2015 and 2016 [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Toxoplasmosis Molecular Testing Discrepancy in a Case of Asymptomatic Microcephaly

Friedrich¹,

Bischoff²,

Castro³

et al. 2017

Pediatric Infect Dis

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Introduction: Microcephaly is a congenital anomaly associated with a wide range of etiological factors such as infections, medications/substances, genetic abnormalities and radiation. Environmental factors that are teratogenic must also be included in the differential diagnosis as common etiologies. In this report we describe a neonate with microcephaly whose molecular tests showed conflicting results in regards to the etiology of the condition.

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Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation

Abstract: Brazilian Ministry of Health, Pan American Health Organization, and Wellcome Trust.

Cited by 531 publications

References 19 publications

Spread of Zika virus in the Americas

Spread of Zika virus in the Americas

Neuroimaging findings of Zika virus infection: a review article

Toxoplasmosis Molecular Testing Discrepancy in a Case of Asymptomatic Microcephaly

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