Congenital syphilis presenting with nephrotic syndrome and leucocytoclastic vasculitis

Çam, Halit; Taytan, Y.; Aji, Dolly Yafet; Bilgi, Zeynep; Aydemir, Erol; Demirkesen, Cüyan

doi:10.1111/j.1468-3083.2004.00933.x

Cited by 15 publications

(13 citation statements)

References 3 publications

(6 reference statements)

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“…There have been reports concerning vasculitis in acquired and congenital syphilis [18][19][20][21]. Leucocytoclastic vasculitis of post-capillary venules in papulopurpuric lesions of the dermis is reported in congenital syphilis [20]. Small vessels in the eye might also be involved and the cluster of shaped chorio-retinal atrophy in our patients also suggested segmental vasculitis in choriocapillaries, which showed a lobular pattern.…”

Section: Discussionsupporting

confidence: 58%

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Pathological Study of Secondary Glaucoma due to Congenital Syphilis-A New Theory of Vasculitis in the Schlemm’s Canal

Hayashi¹

2012

J Clinic Experiment Ophthalmol

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Congenital syphilis is caused by Treponema pallidum infection through the placenta in the embryonic stage and causes ophthalmic symptoms in childhood and adulthood. Ocular involvement of congenital syphilis consists of interstitial keratitis, anterior uveitis, acute iridocyclitis, chorioretinitis, perivasculitis, optic neuritis and secondary glaucoma. Interstitial keratitis and anterior uveitis usually occur between the ages of 5 and 20 years [1] but secondary glaucoma due to congenital syphilis occurs an extremely long time, 30 or 40 years, after interstitial keratitis [2][3][4]. Knox suggests that low-grade, subclinical recurrence of keratitis involves the trabeculae in the inflammatory process and produces a rapid rise in resistance to aqueous outflow [2]. Sugar supposes that trabecular space obstruction and pathologic alterations cause late glaucoma associated with interstitial keratitis [5] but the mode of obstruction in the angle has not yet been reported. We conducted a histopathological study of secondary glaucoma due to congenital syphilis to clarify the reason for increased intraocular pressure (IOP) using trabeculectomy (TLE) specimens.

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Section: Discussionsupporting

confidence: 58%

“…Segmental validity observed in our study might be explained by the above speculation. There have been reports concerning vasculitis in acquired and congenital syphilis [18][19][20][21]. Leucocytoclastic vasculitis of post-capillary venules in papulopurpuric lesions of the dermis is reported in congenital syphilis [20].…”

Section: Discussionmentioning

confidence: 99%

Pathological Study of Secondary Glaucoma due to Congenital Syphilis-A New Theory of Vasculitis in the Schlemm’s Canal

Hayashi¹

2012

J Clinic Experiment Ophthalmol

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“…The primary involvement of vessels usually presents as syphilitic aortitis affecting the vasa vasorum 6 . Only a few cases of LCV associated with syphilis have been reported 7–9 . Our case suggests that leukocytoclastic vasculitis be included in the possible histologic features of primary syphilis.…”

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confidence: 63%

Syphilis showing leukocytoclastic vasculitis

2010

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“…Another study in Brazil identified nephrotic syndrome in 2 (5.3%) of 38 infants that were diagnosed with congenital syphilis at birth or within the first 4 weeks of life 5) . Appropriate penicillin and supportive therapy can allow complete clinical recovery from these conditions 1,[5][6][7] .…”

Section: Discussionmentioning

confidence: 99%

“…Addi-tional symptoms such as fever, anemia, renal manifestations, and pneumonia alba can also be observed 1,2) . This paper presents a case of congenital syphilis with nephrotic syndrome and pneumonia alba in a newborn delivered by a mother that did not receive prenatal care.…”

Section: Introductionmentioning

confidence: 99%

Congenital Syphilis: An Uncommon Cause of Gross Hematuria, Skin Rash, and Pneumonia

Shim

Kim

Lee

et al. 2014

Korean J Pediatr Infect Dis

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Although congenital syphilis can be prevented with prenatal screening, the disease remains problematic. Currently, there are no cases that describe hematuria and pneumonia related to congenital syphilis. We report a case of congenital syphilis that involved nephrotic syndrome and pneumonia alba in a 22-day-old male infant whose mother did not receive adequate prenatal care. The congenital syphilis diagnosis was confirmed with a serologic test and the patient recovered with penicillin treatment. Clinical findings may be subtle in neonates and delayed recognition occurs frequently, thus complete prenatal screening is critical for congenital syphilis prevention. Immediate serologic testing should be performed to obtain a differential diagnosis if an infant is delivered by a mother that has not received appropriate prenatal examinations.

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Congenital syphilis presenting with nephrotic syndrome and leucocytoclastic vasculitis

Cited by 15 publications

References 3 publications

Pathological Study of Secondary Glaucoma due to Congenital Syphilis-A New Theory of Vasculitis in the Schlemm’s Canal

Pathological Study of Secondary Glaucoma due to Congenital Syphilis-A New Theory of Vasculitis in the Schlemm’s Canal

Syphilis showing leukocytoclastic vasculitis

Congenital Syphilis: An Uncommon Cause of Gross Hematuria, Skin Rash, and Pneumonia

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