Congenital self-healing histiocytosis

Bonifazi, E.

doi:10.1001/archderm.118.4.267

Cited by 27 publications

(3 citation statements)

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“…Childhood pure cutaneous histiocytosis X (CPCHX) was first described in 1953 (7). Subsequently, about 20 additional cases bave been reported (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). The onset of lesions is usually prior to 2 years of age.…”

Section: Discussionmentioning

confidence: 99%

Childhood Self‐Healing Histiocytosis X

Pujol

Moreno

López

et al. 1988

Pediatric Dermatology

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A 6-month-old boy had histiocytosis X limited to the skin and oral mucosa, which regressed spontaneously over a period of six months. We review the subsets of autoinvolutive histiocytosis X with special emphasis on the dermatologic manifestations. Childhood self-healing histiocytosis X is a benign condition that should be differentiated from self-healing reticulohistiocytosis (Hashimoto-Pritzker type).

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Section: Discussionmentioning

confidence: 99%

Childhood Self‐Healing Histiocytosis X

Pujol

Moreno

López

et al. 1988

Pediatric Dermatology

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“…Only seven of the described cases of congenital self-healing reticulohistiocytosis have been investigated ultrastructurally [2,5,8,[10][11][12][13]. Electron microscopical features include dense bodies (in 5 out of 7 cases), worm-like particles (in 2 out of 7) and rod-or racket-shaped Langerhans granules, so-called Bitbeck granules (in 4 out of 7; present in 10%-25% of the turnout cells) in the cytoplasm of the infiltrating cells.…”

Section: Discussionmentioning

confidence: 99%

Congenital self-healing non-Langerhans cell histiocytosis

et al. 1988

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Clinical, morphological, ultrastructural and immunological studies were performed in a case of congenital self-healing non-Langerhans cell histiocytosis. The patient showed several aspects that have not been published before: a large nodule in the vulvar region, vesiculobullous elements and pneumonia (asymptomatic). The relationship of the vesicles and pneumonia to the histiocytic disorder is not clear. Ultrastructurally, worm-like (comma-shaped) particles, dense bodies and Birbeck granules were not found. Histiocytes were Leu-6 negative, and S100 (partly), Leu M3 and HLA-DR positive. Positive reactions were also obtained with anti-lysozyme and non-specific esterase. Several aspects of this case and of others described previously are discussed.

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“…The presence of isolated cutaneous LCG has been described by several groups. [54][55][56][57] The clinical manifestations of one variant, congenital selfhealing cutaneous histiocytosis, have been summarized by Bonifazi and associates 57 as follows: (1) presence at birth of multiple, disseminated, elevated, firm, large or small red-brown nodules; (2) involvement limited to the skin; and (3) spontaneous regression within a few months, usually associated with the formation of central areas of cavitation and brown crusts. Apparently isolated cutaneous histiocytosis has also been observed in older children and adults and may follow a more chronic course.…”

Section: Cutaneous Lcgmentioning

confidence: 99%