Congenital malformations in infants conceived following assisted reproductive technology in comparison with spontaneously conceived infants

Farhi, Adel; Reichman, Brian; Boyko, Valentina; Mashiach, Shlomo; Hourvitz, Ariel; Margalioth, Ehud J.; Levran, David; Calderon, Ilan; Orvieto, Raoul; Ellenbogen, A.; Meyerovitch, Joseph; Ron-El, Raphaël; Lerner‐Geva, Liat

doi:10.3109/14767058.2013.776535

Cited by 29 publications

(37 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of the 21 articles reviewed, 19 reported increased risk of birth defects, but only 13 had statistically significant results (Hansen et., 2002;Bonduelle et al, 2005;Sánchez-Albisua et al, 2007;Halliday et al, 2010;Davies et al, 2012;Källén et al, 2005;Belva et al, 2007;Fedder et al, 2013;Hansen et al, 2012;Klemetti et al, 2005;Farhi et al, 2013;Funke et al, 2010;Katalinic et al, 2004). Two studies reported that ICSI was not associated with increases in congenital malformations, but none were statistically significant (Sutcliffe et al, 2003;Place & Englert, 2003).…”

Section: Resultsmentioning

confidence: 99%

“…In most of the publications, the authors adjusted the data according to the variables that might have affected the outcomes: seventeen adjusted their data by maternal age (Hansen et al, 2002;Farhangniya et al, 2013;Bonduelle et al, 2005;Sanchez-Albisua et al, 2007;Halliday et al, 2010;Davies et al, 2012;Källén et al, 2005;Belva et al, 2007;Fedder et al, 2013;Ludwig et al, 2009;Ombele et al, 2005;Hansen et al, 2012;Klemetti et al, 2005;Farhi et al, 2013;Bonduelle et al, 2004;Katalinic et al, 2004;Knoester et al, 2008); seven for paternal age (Bonduelle et al, 2005;Davies et al, 2012;Ludwig et al, 2009;Place & Englert, 2003;Bonduelle et al, 2004;Katalinic et al, 2004;Knoester et al, 2008); ten for parity (Hansen et al, 2002;Halliday et al, 2010;Davies et al, 2012;Källén et al, 2005;Sutcliffe et al, 2001;Ombele et al, 2005;Hansen et al, 2012;Klemetti et al, 2005;Bonduelle et al, 2004;Knoester et al, 2008); seven for socio-economic level (Davies et al, 2012;Belva et al, 2007;Ludwig et al, 2009;Sutcliffe et al, 2001;Place & Englert, 2003;Klemetti et al, 2005;…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis

Lacamara¹,

Ortega²,

Villa³

et al. 2017

JBRA Assisted Reproduction

View full text Add to dashboard Cite

Since 1992, the development of intra-cytoplasmic sperm injection (ICSI) has allowed infertile couples and couples affected by severe male factor infertility in particular, many of which with a history of failed traditional IVF, to become parents. This has generated considerable controversy over the safety of the procedure for the offspring. This systematic review seeks to determine whether evidence indicates that the use of ICSI increases the risk of congenital malformation in children born from singleton pregnancies versus naturally conceived children. Twenty-one of the 104 publications listed in the literature search were included in the analysis. Observational studies reported mostly an increased risk for congenital malformation; the risk of congenital malformations is 7.1% in ICSI and 4.0% in the general population (OR 1.99 (95% CI [1.87 -2.11]). However, attributing higher risk solely to ICSI might seem far-fetched, as in vitro and simulation procedures, patient diseases, and ICSI indication may also be associated with higher risk of malformation.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis

Lacamara¹,

Ortega²,

Villa³

et al. 2017

JBRA Assisted Reproduction

View full text Add to dashboard Cite

show abstract

“…Naturally conceived human embryos are produced by fusion of sperm and egg in a woman's reproductive tract, a process that can be replicated, although imperfectly [185][186][187], by in vitro fertilization. Recent work has shown that human embryos capable of surviving to the blastocyst stage can be produced by cloning [188].…”

Section: Discussionmentioning

confidence: 99%

Totipotency: What It Is and What It Is Not

Condic

2014

Stem Cells and Development

118

View full text Add to dashboard Cite

There is surprising confusion surrounding the concept of biological totipotency, both within the scientific community and in society at large. Increasingly, ethical objections to scientific research have both practical and political implications. Ethical controversy surrounding an area of research can have a chilling effect on investors and industry, which in turn slows the development of novel medical therapies. In this context, clarifying precisely what is meant by ''totipotency'' and how it is experimentally determined will both avoid unnecessary controversy and potentially reduce inappropriate barriers to research. Here, the concept of totipotency is discussed, and the confusions surrounding this term in the scientific and nonscientific literature are considered. A new term, ''plenipotent,'' is proposed to resolve this confusion. The requirement for specific, oocyte-derived cytoplasm as a component of totipotency is outlined. Finally, the implications of twinning for our understanding of totipotency are discussed. HighlightsInaccurate use of the term ''totipotent'' by scientists creates unnecessary ethical controversy. Public concern over producing embryos by reprogramming reflects confusion over totipotency. Twinning by blastocyst splitting does not provide scientific evidence for totipotency.What Is Totipotency?

show abstract

“…[4][5][6][7][8][9][10][11][12] Kimi araştırmacılar YÜT çoğul gebeliklerinin spontan gebeliklerden perinatal özellik-ler açısından bir fark içermediğini iddia ederken, kimi araştırmacılar da YÜT çoğul gebeliklerinin ekstra risk taşıdığını ileri sürmüşlerdir. [9][10][11][12] Risk olarak belirtilen durumlar doğumsal malformasyon, preterm doğum, iri doğum ağırlığı ve sezaryen ile doğum olarak sırala-nabilir. [9][10][11] Biz de çalışmamızda YÜT ile elde edilen ço-ğul gebelikler ile spontan çoğul gebeliklerin perinatal akıbetlerini karşılaştırmayı amaçladık.…”

Section: Introductionunclassified

“…[9][10][11][12] Risk olarak belirtilen durumlar doğumsal malformasyon, preterm doğum, iri doğum ağırlığı ve sezaryen ile doğum olarak sırala-nabilir. [9][10][11] Biz de çalışmamızda YÜT ile elde edilen ço-ğul gebelikler ile spontan çoğul gebeliklerin perinatal akıbetlerini karşılaştırmayı amaçladık. Spontan ve YÜT çoğul gebeliklerinin perinatal akıbet karşılaştırmaları Tablo 3'te sunuldu.…”

Section: Introductionunclassified

Perinatal outcomes of multiple pregnancies after assisted reproductive technology

Özkan¹,

Atılgan²,

Atli³

et al. 2013

J Kartal TR

View full text Add to dashboard Cite

ÖzetAmaç: Yardımcı üreme teknikleri (YÜT) ile elde edilen çoğul gebeliklerin, spontan çoğul gebeliklerden perinatal özellik-ler bakımından bir fark gösterip göstermediğini araştırmayı amaçladık. Gereç ve Yöntem:Bu geriye dönük kesitsel çalışmada 2010 ve 2013 yılları arasında doğum yaptırılan 54 çoğul (53 ikiz, 1 üçüz) gebelik olgusunun perinatal özellikleri incelendi. Tüm olguların perinatal özellikleri hasta dosyaları ve kayıtlardan toplandı. Bulgular:Ortalama anne yaşı, gravida ve parite sırasıyla 29.5±5.8 yıl, 2.1±1.7 adet ve 1±1.7 adet idi. Gebeliklerin %68.5'i spontan, %25.9'u intrasitoplazmik sperm injeksiyonu-embriyo transferi sonrası ve %5.6'sı intrauterin inseminasyon sonrası idi. Hamile kadınların %35.2'sine tokoliz tedavisi ve olguların %50'sine prepartum betametazon uygulandı. YÜT çoğul gebeliklerinde uygulanan tokoliz oranı, spontan çoğul gebeliklerden yüksek idi (%58.8 ve %24.3, p=0.01). YÜT çoğul gebeliklerinde diyetle regüle gestasyonel diyabet oranı yüksek (%17.6 ve %2.7) iken; tiroit fonksiyon bozukluğu oranı ise daha düşük (%5.9 ve %13.5) idi.Sonuç: Bizim çalışma popülasyonumuzda YÜT çoğul gebeliklerinde preterm eylem gelişme riski, spontan çoğul gebeliklere kıyasla daha yüksek oranda gözlendi.

show abstract

Congenital malformations in infants conceived following assisted reproductive technology in comparison with spontaneously conceived infants

Abstract: Infants born following ART were at significantly increased risk for congenital malformations compared to live birth conceived spontaneously.

Cited by 29 publications

References 32 publications

Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis

Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis

Totipotency: What It Is and What It Is Not

Perinatal outcomes of multiple pregnancies after assisted reproductive technology

Contact Info

Product

Resources

About