Congenital iris ectropion uveae presenting with glaucoma in infancy

Laaks, Debbie; Freeman, Nicola

doi:10.1016/j.jaapos.2012.11.010

Cited by 9 publications

(2 citation statements)

References 6 publications

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“…3,6,[11][12][13] Glaucoma in these patients is often refractory to topical and laser therapy resulting in the need for filtering surgery. 3,6,[11][12][13][14][15][16][17][18][19][20] The only report we found about the use of ALT for CEU is from Ritch et al, 6 over four patients. In two cases they performed ALT after the failure of trabeculectomy, repeated ALT after six months and achieved IOP control by adding topical therapy (total follow-up length not reported, but greater than one year).…”

Section: Discussionmentioning

confidence: 99%

Argon laser trabeculoplasty for congenital ectropion uveae: Case report and review of the literature

Incandela

Ferreri

Sisto

et al. 2023

European Journal of Ophthalmology

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A 18-year-old woman with unilateral glaucoma secondary to congenital ectropion uveae (CEU) in the right eye, without other systemic and ocular associations. Intraocular pressure (IOP) was uncontrolled under topical therapy. The visual field (VF) was within normal limits; retinal nerve fiber layer (RNFL) thickness, as evaluated by Optical Coherence Tomography (OCT), was reduced. The patient refused surgical intervention. After evaluation of the iridocorneal angle, ALT was performed as follows: 95 spots were applied for the 270 ° of visible trabecular meshwork using a laser beam diameter of 50 μm, an exposure time of 0.1 s and a power of 750 mw). Mean IOP in the right eye, as evaluated by diurnal tonometric curve, was 10 mmHg, 16 mmHg and 20 mmHg respectively one month, four months and eight months after ALT, with no additional topical therapy, and 18 mmHg twelve months after ALT with topical therapy. CEU is a rare, non-progressive anomaly characterized by the proliferation of iris pigment epithelium on anterior surface of iris; glaucoma, in this disorder, is often poorly controlled with medical therapy alone. In a phase of initial glaucomatous damage and with a not particularly high IOP, as in this case, ALT could be an alternative therapeutic option at least in the short-term, when surgery is not feasible immediately. In fact, given its limited effectiveness over time, ALT can be used as a temporary control measure of IOP, pending surgery to become feasible.

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Section: Discussionmentioning

confidence: 99%

Argon laser trabeculoplasty for congenital ectropion uveae: Case report and review of the literature

Incandela

Ferreri

Sisto

et al. 2023

European Journal of Ophthalmology

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“…13,14 Only few reports exist on the medical and surgical management of glaucoma in CEU. 1,2,[15][16][17] These include goniotomy, trabeculotomy, primary combined trabeculotomy-trabeculectomy (CTT) and trabeculectomy without or with mitomycin-C (MMC). The aim of the present study was to report the surgical outcomes of the management of glaucoma in children with CEU over a 30-year period (1990 to 2019) by a single surgeon at a tertiary eye care center in South India.…”

Section: Introductionmentioning

confidence: 99%

Glaucoma management in congenital ectropion uveae: Surgical outcomes from a large tertiary referral center in South India

Mandal

Gothwal

2022

European Journal of Ophthalmology

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Purpose To evaluate the long-term outcomes of glaucoma management in patients with congenital ectropion uveae (CEU) over a period of three decades at a single large referral tertiary eye care center. Methods Retrospective chart review of all patients with CEU treated surgically from 1990 to 2019 was performed. Primary combined trabeculotomy-trabeculectomy (CTT), trabeculectomy with and without mitomycin-C (MMC) (0.2 mg/mL for 1 min) and transscleral cyclophotocoagulation (TSCPC) were performed. Intraocular pressure (IOP) ≥6 and ≤16 mmHg without medications was considered as complete success and IOP≤ 16 mmHg with the use of upto 2 medications as qualified success. Results A total of 26 eyes of 21 patients were identified with a median age of 7 years (range, 6 days to 19 years) at the time of glaucoma surgery. Median follow-up was 51.1 months (range, 7–244.6 months). Primary CTT was performed in 17 eyes (65%), trabeculectomy in 5 eyes (19%) with application of MMC in 2 eyes, and 3 eyes (12%) underwent TSCPC. One painful blind eye (4%) underwent evisceration. Mean IOP reduced from 30.8 ± 7.6 mmHg on a mean of 1.3 ± 0.8 glaucoma medications preoperatively to a mean IOP of 15.2 ± 5.9 mmHg (P < 0.0001) on a mean of 0.2 ± 0.5 medications postoperatively at final follow-up (P = 0.0009). Complete success was achieved in 20 eyes, and qualified success in 2 eyes. Conclusions CTT is a safe and efficacious primary procedure for management of early-onset glaucoma in CEU. Trabeculectomy with or without adjuvant MMC is a viable second line of treatment in late-onset glaucoma with CEU for IOP control.

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Uvea

Yanoff¹,

Sassani²

2020

Ocular Pathology

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Congenital iris ectropion uveae presenting with glaucoma in infancy

Cited by 9 publications

References 6 publications

Argon laser trabeculoplasty for congenital ectropion uveae: Case report and review of the literature

Argon laser trabeculoplasty for congenital ectropion uveae: Case report and review of the literature

Glaucoma management in congenital ectropion uveae: Surgical outcomes from a large tertiary referral center in South India

Uvea

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