Congenital hypertrophic pyloric stenosis: A gastrin hypothesis pursued

Rogers, Ian Munro; Macgillion, F.; Drainer, Ian K.

doi:10.1016/0022-3468(76)90282-7

Cited by 10 publications

(5 citation statements)

References 18 publications

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“…Moreover a direct action of gastrin on the pyloric circular muscle has been demonstrated (Rogers et al, 1976), in addition to an increase of antral mobility induced by the hormone in vitro (Bennett, 1965) and in vivo (Heinische, 1967;Isenberg and Grossman, 1969). Gastrin released by vagal reflexes may act in newborn babies as a mediator of perinatal environmental stress factors (Dodge, 1975) to produce pyloric contraction or spasm, or both, and pyloric hypertrophy; alternatively the pyloric hold-up could be increased by a self-perpetuating mechanism: antral distension with milk and gastrin release (Dodge, 1972;Rogers et al, 1975).…”

mentioning

confidence: 97%

“…Pyloric stenosis has been observed in newborn pups after repeated injections of pentagastrin to pregnant bitches during the final stages of gestation, and the most pronounced changes were seen in 30-day-old pups that continued to receive pentagastrin after birth (Dodge, 1970;Karim et al, 1974;Dodge and Karim, 1976). Moreover a direct action of gastrin on the pyloric circular muscle has been demonstrated (Rogers et al, 1976), in addition to an increase of antral mobility induced by the hormone in vitro (Bennett, 1965) and in vivo (Heinische, 1967;Isenberg and Grossman, 1969). Gastrin released by vagal reflexes may act in newborn babies as a mediator of perinatal environmental stress factors (Dodge, 1975) to produce pyloric contraction or spasm, or both, and pyloric hypertrophy; alternatively the pyloric hold-up could be increased by a self-perpetuating mechanism: antral distension with milk and gastrin release (Dodge, 1972;Rogers et al, 1975).…”

mentioning

confidence: 99%

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Serum gastrin levels in hypertrophic pyloric stenosis of infancy. Response to a gastrin secretion test.

Hambourg¹,

Mignon²,

Ricour³

et al. 1979

Archives of Disease in Childhood

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SUMMARY The aim of this study was to look for a difference in fasting serum gastrin levels or in serum gastrin response to oral feeding between infants with hypertrophic pyloric stenosis and normal controls. Fasting serum gastrin levels were measured by radioimmunoassay in 10 patients with pyloric stenosis, before pyloromyotomy and 7 and 15 days after it, and in 11 controls. In addition, the serum gastrin responses to a casein hydrolysate meal were studied in both groups (in the patients, 7 days after operation). The fasting serum gastrin levels in the patients did not differ from those in the controls before operation, but they did so after it. The serum gastrin response to feeding in patients after pyloromyotomy was no greater than in controls.

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mentioning

confidence: 97%

mentioning

confidence: 99%

Serum gastrin levels in hypertrophic pyloric stenosis of infancy. Response to a gastrin secretion test.

Hambourg¹,

Mignon²,

Ricour³

et al. 1979

Archives of Disease in Childhood

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“…A recent report in which gastrin is shown to have a direct effect upon pyloric smooth muscle contraction (Rogers et al, 1976) supports the gastrin hypothesis in IHPS. Results from the present study, revealing higher serum gastrin levels in most IHPS infants compared to normal infants, further support a role for gastrin in human IHPS.…”

Section: Discussionmentioning

confidence: 53%

Increased serum immunoreactive gastrin levels in idiopathic hypertrophic pyloric stenosis.

Bleicher¹,

Shandling²,

Zingg³

et al. 1978

Gut

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SUMMARY The serum immunoreactive gastrin (1RG) level in infants with confirmed idiopathic hypertrophic pyloric stenosis (IHPS) has been determined and compared to that found in vomiting infants without IHPS, in normal infants, and in normal adults. The mean serum IRG level of normal infants (103 ± 9 pg/ml (mean + SEM) exceeded that of normal adults (28 + 5 pg/ml). The preoperative mean serum IRG level in IHPS infants (256 + 26 pg/ml) was significantly higher than that of both normal infants and vomiting infants without IHPS (93 ± 9 pg/ml). (Dodge, 1972;Dodge and Karim, 1976). At present, the status of the gastrin hypothesis in human IHPS is uncertain because evidence has been presented both to support (Spitz and Zail, 1976) and refute (Rogers et al., 1975) it. No systematic evaluation of fasting and postprandial serum IRG levels in infants has been undertaken to establish the normal fasting and stimulated ranges of IRG. Available evidence indicates that a neonatal hypergastrinaemia does exist (Rogers et al., 1974;Sann et al., 1975;Euler et al., 1977).

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“…Intravenous infusions of gastrin delay gastric emptying (22), perhaps directly (23) or indirectly by provoking gastric hyperacidity (14).…”

Section: Gastrin Infusionsmentioning

confidence: 99%

The enigma of pyloric stenosis. Some thoughts on the aetiology

Rogers

1997

Acta Paediatrica

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Congenital hypertrophic pyloric stenosis: A gastrin hypothesis pursued

Cited by 10 publications

References 18 publications

Serum gastrin levels in hypertrophic pyloric stenosis of infancy. Response to a gastrin secretion test.

Serum gastrin levels in hypertrophic pyloric stenosis of infancy. Response to a gastrin secretion test.

Increased serum immunoreactive gastrin levels in idiopathic hypertrophic pyloric stenosis.

The enigma of pyloric stenosis. Some thoughts on the aetiology

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