Congenital cytomegalovirus infection in preterm and full-term newborn infants from a population with a high seroprevalence rate

Yamamoto, Aparecida Yulie; Mussi-Pinhata, Marisa Márcia; P, Cristina; Pinto, Gabriela dos Santos; Figueiredo, Moraes; Sm, Jorge

doi:10.1097/00006454-200102000-00014

Cited by 81 publications

(65 citation statements)

References 20 publications

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“…The incidence of CI varies between 0.2% and 2.5% in all live births in both preterm and full-term newborns [3,4]. Several studies of PI, mainly in preterm infants, have shown a wide range of prevalence, from 5% to 50% [5,6].…”

Section: Introductionmentioning

confidence: 99%

Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity

Arellano‐Galindo

Villanueva-García

Cruz-Ramirez

et al. 2014

J Infect Dev Ctries

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Introduction: Congenital (CI) and perinatal cytomegalovirus (CMV) infections (PI) can be linked to maternal CMV seropositivity, with fatal consequences in preterm newborns. GB genotyping has been used to analyze genotypic similarity in mothers and infants. The frequency of CMV infection in the context of maternal seropositivity and the viral gB genotypes as well as the genotypic similarity in mothers and preterm infants were investigated. Methodology: Saliva samples and dry blood spots (DBS) were taken weekly from preterm newborns from birth until the first month of life, and breast milk samples were taken from their mothers weekly during the first month of lactation. CMV IgG seroprevalence of the mothers and CI or PI in the infants were established. The gB status and genotypic similarities were established retrospectively in DBS and in the breast milk samples. Results: In total, 387 neonates and 375 mothers were enrolled. The maternal CMV-positive IgG serology was 97.3% (365/375). Neonatal CMV was found in 5.1% (20/387) of newborns, and one infant presented with CMV-compatible symptoms. CI was 2.5% and PI in the first month after birth was 11.8%. GB2 was the most prevalent genotype and was also the genotype preferentially transmitted to newborns by mothers with mixed infections. Conclusions: CMV PI and CI in preterm infants from highly seropositive mothers was high, but the rate of symptomatic infection was low. The prevalent genotype was gB2, and this genotype was preferentially transmitted to newborns by mothers with mixed infections.

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Section: Introductionmentioning

confidence: 99%

Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity

Arellano‐Galindo

Villanueva-García

Cruz-Ramirez

et al. 2014

J Infect Dev Ctries

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“…The prevalence of infection increases with age, and is higher for those with a lower socioeconomic status, and people living in developing countries. Congenital CMV infection occurs in approximately 0.2 to 2.4% of all live births [5][6][7]. Perinatal infection occurs more frequently than congenital infection and thus many more are infected within the first year.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus Infection in Infantile Hepatitis

2012

Pediatr Gastroenterol Hepatol Nutr

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“…In France, the rate of congenital infection is also in this range, approximately 1% [2]. In Brazil, studies showed prevalence from 2.1% [3] to as high as 6.2% [4]. Generally, 10% of infected children are symptomatic, while 85-90% are asymptomatic.…”

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confidence: 99%

Prognostic markers of symptomatic congenital cytomegalovirus infection

Romanelli¹,

Jf²,

Jacquemard³

2008

Braz J Infect Dis

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The objective of this research was to identify maternal and fetal characteristics as prognostic markers of congenital cytomegalovirus (CMV) infection. This is a descriptive study of 13 cases of congenital CMV infection referred to Institute de Puericulture et Perinatologie de Paris (IPP) from January 2005 to October 2006. Amniotic fluid puncture was performed to research CMV polimerase chain reaction (PCR). Cordocentesis and cord blood samples at delivery were also analyzed to determinate fetal platelets count, GGT, ASAT, ALAT, CMV-DNA and IgM antibody. Variables of symptomatic and asymptomatic infants were then compared. Data were analyzed by SPSS -15.0. Mean gestational age of amniocentesis was 24.6 weeks and there was no difference of mean viral load in amniotic fluid considering infant features. Mean gestational age of cordocentesis was 26.1 weeks. There were no statistical differences of fetal viral load, IgM, platelets, GGT, ASAT and ALAT analyzed at cordocentesis samples, but at delivery, mean values of IgM and ASAT of fetal blood were increased in symptomatic ones (p= 0.03 for both parameters). When considering groups with normal and abnormal parameters, ASAT of cordon samples was also increased in symptomatic infants (p= 0.02). Sensibility, specificity, positive and negative predictive value of fetal ultrasound anomalies to detect symptomatic infants were, respectively, 80%, 62.5%, 57.1% and 83.3%. Thus, identification of markers of CMV symptomatic infants should be aimed. Prenatal diagnosis, identification and follow up of congenital CMV infected infants are important to consider treatment for symptomatic infants, trying to avoid or reducing some possible sequels.

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Congenital cytomegalovirus infection in preterm and full-term newborn infants from a population with a high seroprevalence rate

Cited by 81 publications

References 20 publications

Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity

Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity

Cytomegalovirus Infection in Infantile Hepatitis

Prognostic markers of symptomatic congenital cytomegalovirus infection

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