Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology—a position statement of the development, anatomy, and pathology ESC Working Group

Pérez‐Pomares, José M.; Pompa, José Luis de la; Franco, Diego; Henderson, Deborah J.; Ho, Siew Yen; Houyel, Lucile; Kelly, Robert G.; Sedmera, David; Sheppard, Mary N.; Sperling, Silke; Thiene, Gaetano; Hoff, Maurice J.B. van den; Basso, Cristina

doi:10.1093/cvr/cvv251

Cited by 165 publications

(153 citation statements)

References 85 publications

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“…The causal relationship among congenital coronary anomalies and other congenital cardiac defects is not currently understood. However, it is quite possible that they share common pathogenic mechanisms that influence each other through reciprocal interactions (Perez-Pomares et al, 2016). …”

Section: Discussionmentioning

confidence: 99%

“…In the above-mentioned examples the coronary vascular defects were often accompanied by hypoplastic myocardium and, in some cases, by other cardiac defects in outflow tract formation, chamber formation and septation (Sucov et al, 1994;Lin et al, 2010;Billings et al, 2013). The causal relationship among congenital coronary anomalies and other congenital cardiac defects is not currently understood though is quite possible that they share common pathogenic mechanisms that influence each other through reciprocal interactions (Perez-Pomares et al, 2016). In the current study, we observed that RA treatment of MEC1 epicardial cells caused a reduction in the expression of factors involved in HIF1asignaling and angiopoiesis.…”

Section: Developmental Dynamicsmentioning

confidence: 99%

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Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature

Wang

Huang

Castillo

et al. 2018

Developmental Dynamics

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Section: Discussionmentioning

confidence: 99%

Section: Developmental Dynamicsmentioning

confidence: 99%

Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature

Wang

Huang

Castillo

et al. 2018

Developmental Dynamics

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“…Congenital coronary artery anomalies are frequently observed and of major importance in cardiology and cardiac surgery, because of their association with myocardial ischemia and sudden death. An extensive description of these abnormalities has recently been published (Perez‐Pomares et al, ).…”

Section: Epicardium and Its Derivativesmentioning

confidence: 99%

Development of the human heart

Buijtendijk

Barnett

Hoff

2020

American J of Med Genetics Pt C

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In 2014, an extensive review discussing the major steps of cardiac development focusing on growth, formation of primary and chamber myocardium and the development of the cardiac electrical system, was published. Molecular genetic lineage analyses have since furthered our insight in the developmental origin of the various component parts of the heart, which currently can be unambiguously identified by their unique molecular phenotype. Moreover, genetic, molecular and cell biological analyses have driven insights into the mechanisms underlying the development of the different cardiac components. Here, we build on our previous review and provide an insight into the molecular mechanistic revelations that have forwarded the field of cardiac development. Despite the enormous advances in our knowledge over the last decade, the development of congenital cardiac malformations remains poorly understood. The challenge for the next decade will be to evaluate the different developmental processes using newly developed molecular genetic techniques to further unveil the gene regulatory networks operational during normal and abnormal cardiac development.

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“…We found that principal component 1 (PC1) showed that iPSC-CVPCs correspond to an intermediate state between the iPSCs and adult samples, suggesting that the derived CMs and EPDCs are similar to immature cardiac cells ( Figure 2D). PC2 divided the samples based on embryonic origins, namely the myocardium (left ventricles and atrial appendages) and epicardium (coronaries and aorta) (Moorman et al, 2003;Perez-Pomares et al, 2016). This analysis shows that derived iPSC-CMs and iPSC-EPDCs lie on different developmental trajectories, with the CMs corresponding to immature myocardium and the EPDCs to immature epicardium.…”

Section: Ipsc-cvpcs Are Composed Of Immature Cms and Epdcsmentioning

confidence: 99%

Human iPSC gene signatures and X chromosome dosage impact response to WNT inhibition and cardiac differentiation fate

D’Antonio‐Chronowska

Donovan

Benaglio

et al. 2019

Preprint

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Non-genetic variability in human induced pluripotent stem cell (iPSC) lines impacts their differentiation outcome, limiting their utility for genetic studies and clinical applications. Despite the importance of understanding how non-genetic molecular variability influences iPSC differentiation outcome, large-scale studies capable of addressing this question have not yet been conducted. Here, we performed 258 directed differentiations of 191 iPSC lines using established protocols to generate iPSC-derived cardiovascular progenitor cells (iPSC-CVPCs). We observed cellular heterogeneity across the iPSC-CVPC samples due to varying fractions of two cell types: cardiomyocytes (CMs) and epicardium-derived cells (EPDCs). Analyzing the transcriptomes of CM-fated and EPDC-fated iPSCs discovered that 91 signature genes and X chromosome dosage differences influence WNT inhibition response during differentiation and are associated with cardiac fate. Analysis of an independent set of 39 iPSCs differentiated to the cardiac lineage confirmed shared sex and transcriptional differences that impact cardiac fate outcome. The scale and systematic approach of our study enabled novel insights into how iPSC transcriptional and X chromosome gene dosage differences influence WNT signaling during differentiation and hence cardiac cell fate.

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Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology—a position statement of the development, anatomy, and pathology ESC Working Group

Cited by 165 publications

References 85 publications

Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature

Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature

Development of the human heart

Human iPSC gene signatures and X chromosome dosage impact response to WNT inhibition and cardiac differentiation fate

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