2016
DOI: 10.1148/radiol.2016161584
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Abstract: Purpose To document the imaging findings associated with congenital Zika virus infection as found in the Instituto de Pesquisa in Campina Grande State Paraiba (IPESQ) in northeastern Brazil, where the congenital infection has been particularly severe. Materials and Methods From June 2015 to May 2016, 438 patients were referred to the IPESQ for rash occurring during pregnancy or for suspected fetal central nervous system abnormality. Patients who underwent imaging at IPESQ were included, as well as those with d… Show more

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Cited by 259 publications
(319 citation statements)
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“…17 Suspected cases were classified as possible CZS when the above-mentioned items 1 or 4 were unknown or not present but the infant was born in an epidemic area and there was microcephaly and brain imaging suggestive of CZS. 8,13,14 The group of infants with microcephaly at birth was compared with the group without microcephaly and with the group with postnatal microcephaly. We also joined groups and compared: 1) group with microcephaly at birth with group without microcephaly at birth (postnatal microcephaly ϩ without microcephaly); and 2) group with microcephaly (microcephaly at birth ϩ postnatal microcephaly) with group without microcephaly.…”
Section: Methodsmentioning
confidence: 99%
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“…17 Suspected cases were classified as possible CZS when the above-mentioned items 1 or 4 were unknown or not present but the infant was born in an epidemic area and there was microcephaly and brain imaging suggestive of CZS. 8,13,14 The group of infants with microcephaly at birth was compared with the group without microcephaly and with the group with postnatal microcephaly. We also joined groups and compared: 1) group with microcephaly at birth with group without microcephaly at birth (postnatal microcephaly ϩ without microcephaly); and 2) group with microcephaly (microcephaly at birth ϩ postnatal microcephaly) with group without microcephaly.…”
Section: Methodsmentioning
confidence: 99%
“…Reduction in brain volume is present in all infants with microcephaly, while brain volume is preserved in infants without microcephaly with significant differences. Therefore, the normal head size in the normocephalic group is not due to hydrocephalus 14 but due to less severe brain damage. Volumetric MR imaging studies could be useful for better characterizing the reduction of brain volume.…”
Section: Neuroimaging Features Of the Congenital Zika Syndrome Spectrummentioning
confidence: 97%
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“…This fact could explain the increased number of microcephaly cases reported in Brazil. Other congenital malformations, such as lissencephaly, ventriculomegaly, cerebellar hypoplasia, cortical atrophy with cerebral calcifications, and arthrogryposis have also been described in cases of ZIKV congenital infection 5,29,30 . With respect to these findings, Garcez et al indicated that ZIKV may cause impairment in the growth of neural cell population.…”
Section: Warning Of Neurological Complications Of Dengue Zika and Cmentioning
confidence: 99%
“…Many of the clinical and radiographic abnormalities identified in our cohort have been described in prior case series. 27,28 We have observed a variety of neurologic findings, including visual and hearing deficits, seizure activity, hypertonicity, spasticity, hyperreflexia, contractures, dysphagia, and feeding difficulties. A troubling aspect of our study is that children were assessed in early infancy, when some subtle neurologic manifestations of disease are difficult to identify.…”
Section: Discussionmentioning
confidence: 99%