Lenka Zerzankova, Tereza Suchankova, Oldrich Vrana, Nicholas P. Farrell, Viktor Brabec, Jana Kasparkova
AbstractReported herein is a detailed biochemical and molecular biophysics study of the molecular mechanism of action of antitumor dinuclear 6 NH 2 ] (complex 1). This new, longchain bifunctional dinuclear Pt II complex is resistant to metabolic decomposition by sulfurcontaining nucleophiles. The results show that DNA adducts of 1 can largely escape repair and yet inhibit very effectively transcription so that they should persist longer than those of conventional cisplatin. Hence, they could trigger a number …
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