2005
DOI: 10.1001/archderm.141.10.1269
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Confocal Examination of Untreated Fresh Specimens From Basal Cell Carcinoma

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Cited by 29 publications
(22 citation statements)
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References 12 publications
(10 reference statements)
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“…A recent study reported high diagnostic accuracy of 100% for detection of BCCs (Gerger et al , 2005). A later study (Horn et al , 2007) on squamous cell carcinomas from 20 patients yielded sensitivity of 95% and specificity of 96%.…”
Section: Discussionmentioning
confidence: 99%
“…A recent study reported high diagnostic accuracy of 100% for detection of BCCs (Gerger et al , 2005). A later study (Horn et al , 2007) on squamous cell carcinomas from 20 patients yielded sensitivity of 95% and specificity of 96%.…”
Section: Discussionmentioning
confidence: 99%
“…[15] It can image the epidermis and dermis with cellular-level resolution (0.5–1 μm in lateral dimension and 4–5 μm in axial ones) to a depth of 500 μm, producing images representing horizontal planes of the skin. It employs a diode laser at 830 nm with a power, less than 35 mW.…”
Section: Other Diagnostic Techniques For Skin Tumoursmentioning
confidence: 99%
“…Later studies that were conducted on larger sample sizes using RCM-acetic acid approach also reported similar limitations. 27 Therefore, RCM-acetic acid methodology was, subsequently, replaced by FCM imaging again using specific nuclear contrast agents but in fluorescence, such as acridine orange, methylene blue, and toluidine blue; 13,14 methylene blue and toluidine blue primarily stain nucleic acid (DNA and RNA) and are frequently used as conventional histology stains. 13 Acridine orange interacts with the DNA and RNA of the nuclei, without staining collagen tissue.…”
Section: Development Of Confocal Mosaicking Microscopy Imaging Protocmentioning
confidence: 99%
“…25,26 Confocal mosaicking microscopy (CMM) is currently the furthest advanced, being implemented and validated in Mohs surgical settings in real time. [27][28][29][30][31] In these settings, CMM is being integrated into the clinical workflow and has shown high sensitivity and specificity for detecting residual BCC tumors in fresh Mohs surgical excisions. In this article, we assess the progress of CMM-guided Mohs surgery from bench-top development in a laboratory to actual bedside implementation in Mohs surgical settings.…”
Section: Introductionmentioning
confidence: 99%