Confocal Examination of Untreated Fresh Specimens From Basal Cell Carcinoma

The use of confocal laser-scanning microscopy in microsurgery for invasive squamous cell carcinoma

“…2). Moreover, normal skin structures as previously published could be clearly identified 9 (Fig. 3).…”

Multiphoton Laser Scanning Microscopy on Non-Melanoma Skin Cancer: Morphologic Features for Future Non-Invasive Diagnostics

“…The characteristic features found in the SBCC lesions were increased thickness of the subcorneal epidermis, peripheral palisading of tumor cells in the lower epidermis, and speckled perinuclear fluorescence in the upper epidermis. In one lesion, we observed elongated cells and nuclei polarization in the lower third of the epidermis, which has earlier been described in SBCC lesions using RCLSM in vivo (Gonzalez and Tannous, 2002;Nori et al, 2004;Gerger et al, 2005a). It is not possible to completely exclude the possibility of elongated cells, nuclei polarization, and presence of peripheral palisading at deeper tissue layers in the other five lesions due to the limited imaging depth.…”

Reflectance Confocal Microscopy - Real-Time In Vivo Imaging of Basal and Squamous Cell Carcinomas

“…In an evaluation of the diagnostic accuracy of 12 fresh BCC excisions by RCM, most of the features were highly reliable including tumor cell nuclei and tumor nests [11]. In contradistinction, disintegration of tumor cells, peripheral palisading, and refraction of stroma was hardly useful [11]. The promising results from this study opens avenues for future studies in which RCM can serve as a guide for microsurgery of any type of skin cancer.…”