Confluent and reticulated papillomatosis successfully treated with the aromatic etretinate

Bruynzeel-Koomen, C. A.

doi:10.1001/archderm.120.9.1236

Cited by 15 publications

(15 citation statements)

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“…Lowdose maintenance therapy with etretinate at approximately 10-20 mg/day is needed for long-term treatment in order to prevent relapse [4,5], Recently, some new data demonstrated that keratoderma climactericum of Haxthausen's responded well to etretinate [6], In keratosis lichenoides chronica [7], Kyrlc's disease [8] and con fluent and reticulated papillomatosis [9], some rare hyper-and dyskcratotic diseases, etretinate has been reported to produce good results within 3-4 weeks. Concerning its mechanism of action, etretinate inhibits the migration of neutrophilic and eo sinophilic granulocytes by a direct effect on cell motility [10], probably by changing the cells' capability to respond to chemoattrac tants or by modulating components of the epidermis or basal membrane zone to act as chemoattractants.…”

Section: Etretinatementioning

confidence: 99%

New Indications and New Retinoids

Gollnick¹

1987

Dermatology

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In addition to well-accepted indications, etretinate has a beneficial effect in a variety of other dermatoses such as the hyperkeratotic eczema of the palms and soles, prurigo nodularis, and other nonpsoriatic, sterile, pustular eruptions. Due to its influence on dermal inflammatory processes and immunomodulation of the tissue response, etretinate is effective in cutaneous lupus erythematosus, certain bullous disorders like pemphigus herpetiformis, the persistent variant of Grover’s disease, dermatitis herpetiformis, and bullous pemphigoid. Isotretinoin is reported to be effective in cutaneous sarcoidosis, disseminated granuloma annulare, systemic sclerosis and tumors of the cutaneous appendages. New synthetic retinoids have been developed. Etretin, the main metabolite of etretinate, was shown to be effective and to have a short elimination half-life of – 50 h. Arotinoid ethyl ester and arotinoid-free carboxylic acid are effective in minimal doses 500-fold lower than etretinate. Arotinoid ethyl ester was shown not to increase serum lipids. Arotinoid ethyl sulfone is the first retinoid without bone toxicity in animal experiments. Motretinide is the ethylamide of tretinoin and is reported to be effective in the local treatment of acne. Some of the new poly-aromatic retinoids appear to have sebosuppressive, antikeratinizing and/or anti-inflammatory effects via topical application.

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Section: Etretinatementioning

confidence: 99%

New Indications and New Retinoids

Gollnick¹

1987

Dermatology

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“…Oral etretinate therapy was remarkably effective in our case, although the effects arc reportedly variable [7,12,18]. It has been reported that the etretinate therapy improved glucose tolerance and insulin responses in pa tients with psoriasis [20], Impaired glucose tolerance in our case, however, remained during and after the etretinate therapy.…”

Section: Discussionmentioning

confidence: 49%

“…An unidentified endocrine imbalance including obesity and diabetes mellitus [8,12], an abnormal host reaction to P. orbiculare infection [9] and a keratinization defect [18] have been suggested. In our case, he had a past history of tinea versicolor 3 years before the development of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Confluent and Reticulated Papillomatosis: A Case with Concurrent Acanthosis nigricans Associated with Obesity and Insulin Resistance

1994

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A 19-year-old Japanese man with confluent and reticulated papillomatosis (CRP) is presented. He was an obese and dark-complexioned man, who had impaired glucose tolerance and hyperinsulinemia. The clinical and histological findings were consistent with the diagnosis of CRP. He also had acanthosis nigricans (AN) on his axillae and nape. Neither spores nor hyphae were detected from scales; antifungal treatment had no benefit. Although the reduction of his weight was unsuccessful, oral etretinate therapy resulted in considerable improvement of both CRP and AN. We reviewed previous case reports in terms of the relation between CRP and AN. Although the two conditions are usually differentiated because of their distinctive clinical features, a close relationship was noted between CRP and AN.

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“…Though endocrine abnormalities, especially diabetes mellitus, obesity, thyroid disease, and hypopituitarism have been described [13][14][15][16] , no association to MEN1 has been reported so far. Ultrastructural and immunohistochemical findings indicate an underlying abnormal keratinocyte differentiation or a genetically determined defect of keratinization [17,18] . Alternatively, an abnormal host reaction to Pityrosporum orbiculare infection has been discussed [14,15] .…”

Section: Discussionmentioning

confidence: 99%