Confluent and reticulate papillomatosis

Kellet, J. K.

doi:10.1001/archderm.121.5.587c

Cited by 9 publications

(3 citation statements)

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“…In the first 5 decades, the prevailing concept was that CRP was due to an abnormal host response to Malassezia furfur 15–17. However, as more authors reported inconsistent detection of Malassezia spp.…”

Section: Etiologymentioning

confidence: 99%

Confluent and reticulated papillomatosis: diagnostic and treatment challenges

Lim¹,

Tey²,

Chong³

2016

CCID

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Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud was first typified in 1927. With the help of electron microscopy, it has been elucidated that CRP arises due to aberrant keratinization. However, till date, there is no clear consensus on the etiologic trigger for CRP. Prevailing postulates include a bacterial trigger by Dietzia papillomatosis (type strain N 1280T), an exaggerated cutaneous response to Malassezia furfur, an endocrine basis stemming from insulin resistance, ultraviolet light-induced epidermal change, amyloid deposition, and a loss-of-function mutation in keratin 16. CRP typically presents as asymptomatic hyperpigmented papules and plaques with peripheral reticulation over the nape, axillae, upper chest, and upper back, occasionally with extension superior to the forehead and inferior to the pubic region. Dermoscopy may be used in the evaluation of CRP, but its diagnosis is made on clinical grounds given its nonspecific histopathological findings. Although successful treatment with topical keratolytics, retinoids, or antifungals has been reported, antibiotics, such as minocycline, at anti-inflammatory doses have emerged as a preferred therapeutic option. In this article, we review the diagnostic considerations in CRP and its therapeutic options.

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Section: Etiologymentioning

confidence: 99%

Confluent and reticulated papillomatosis: diagnostic and treatment challenges

Lim¹,

Tey²,

Chong³

2016

CCID

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“…Yeasts of the genus Malassezia are part of the normal mycota of the skin of humans and other warm‐blooded animals. 1 Malassezia yeasts may also have a role in pityriasis (tinea) versicolor, 2 seborrhoeic dermatitis, 3 , 4 seborrhoeic blepharitis, 5 dandruff, 4 ‘ Malassezia folliculitis’, 6 confluent and reticulate papillomatosis 7 and, uncommonly, systemic infections. In the last category, Malassezia species may be associated with catheter‐acquired sepsis, fungaemia and pulmonary infection in neonates; these infections can sometimes be life‐threatening.…”

mentioning

confidence: 99%

In vitro susceptibility of the seven Malassezia species to ketoconazole, voriconazole, itraconazole and terbinafine

Gupta

Kohli

et al. 2000

British Journal of Dermatology

138

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Fifty-five strains, either authentic or ex-type, of seven Malassezia species were investigated for in vitro susceptibility to various concentrations (0.03-64.0 microg/mL) of three azole drugs, ketoconazole, voriconazole and itraconazole, as well as the allylamine terbinafine, using the agar dilution method. All strains of the seven Malassezia species were susceptible to the three azole drugs at low concentrations. M. furfur, M. sympodialis, M. slooffiae, M. pachydermatis, M. globosa, M. obtusa and M. restricta were most sensitive to ketoconazole and itraconazole, with minimum inhibitory concentrations (MICs) ranging from < or = 0.03 to 0.125 microg/mL. The recently introduced antifungal, voriconazole, was also very effective, with MIC80 values < or = 0.03 microg/mL for 80% of strains. MICs of terbinafine against the seven Malassezia species ranged from

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“…Subsequent lesions may develop in the neck, axilla and back. [3][4][5][6] In some patients, the disease can involve shoulders, upper arms and surrounding area of the antecubital and popliteal fossa. [3][4][5][6] It rarely affects the sole, palm or mucous membrane and there was no report of forehead sited CRP in a published work search.…”

mentioning

confidence: 99%