Cone‐beam computed tomographic and histological investigation of regenerative endodontic procedure in an immature mandibular second premolar with chronic apical abscess

Abstract

The present study of a structurally-failed tooth with prior REP demonstrates that the tissue formed within the root canal space was fibrous connective tissue with cementum-like deposition in the canal space. No evidence of dentin- or pulp-like tissue was found.

Histological assessment of human regenerative endodontic procedures (REP) of immature permanent teeth with necrotic pulp/apical periodontitis: A systematic review

“…Concerning the state of the pulp before the initiation of regenerative treatment, two teeth displayed irreversible pulpitis , nine had pulpal necrosis , and ten had apical periodontitis . Two teeth were completely healthy, and their pulps were extirpated , while one had previously initiated root canal treatment and lacked pulp tissue .…”

“…Then, 43 studies were excluded by title and 32 studies were excluded by abstract. Finally, 12 articles met the inclusion criteria after full‐text evaluation .…”

“…Two teeth were completely healthy, and their pulps were extirpated , while one had previously initiated root canal treatment and lacked pulp tissue . Twelve teeth were infected and two not infected . Three teeth had vital pulp or vital pulp remnants (Table ).…”

“…The radiographic findings from 12 teeth showed resolution of the apical lesion and continuation of root maturation with root lengthening, thickening of the dentinal walls and apical closure to different degrees, which were evaluated as successful by the authors . In one case, the tooth was extracted 3.5 weeks after REP, and consequently, there was insufficient time for root maturation .…”

“…All 14 teeth were assessed for routine histological exanimation . Briefly, after fixation and decalcification of the extracted teeth, serial sectioning was performed of paraffin‐embedded or frozen tissue samples .…”