volume 134, issue 11, P2159-2169 2007
DOI: 10.1242/dev.001586
View full text
Sign up to set email alerts

Abstract: The motor protein Kif3a and primary cilia regulate important developmental processes, but their roles in skeletogenesis remain illdefined. Here we created mice deficient in Kif3a in cartilage and focused on the cranial base and synchondroses. Kif3a deficiency caused cranial base growth retardation and dysmorphogenesis, which were evident in neonatal animals by anatomical and microcomputed tomography (CT) inspection. Kif3a deficiency also changed synchondrosis growth plate organization and function, and the se…

Expand abstract