The modulation of small-scale velocity and velocity gradient quantities by concurrent large-scale velocity fluctuations is observed by consideration of the Kullback-Leibler divergence. This is a measure that quantifies the loss of information in modelling a statistical distribution of small-scale quantities conditioned on concurrent positive large-scale fluctuations by that conditioned on negative large-scale fluctuations. It is observed that the small-scale turbulence is appreciably "rougher" when the concurrent large-scale fluctuation is positive in the low-speed side of a fully developed turbulent mixing layer which lends further evidence to the convective scale modulation argument of Buxton & Ganapathisubramani (2014). The definition of the small scales is varied and regardless of whether the small-scale fluctuations are dominated by dissipation or have the characteristic features of inertial range turbulence they are shown to be modulated by the concurrent large-scale fluctuations. The modulation is observed to persist even when there is a large gap in wavenumber space between the small and large scales, although local maxima are observed at intermediate length scales that are significantly larger than the pre-defined small-scales. Finally, it is observed that the modulation of small-scale dissipation is greater than that for enstrophy with the modulation of the vortex stretching term, indicative of the interaction between strain-rate and rotation, being intermediate between the two.