Concurrent eosinophilic fasciitis and cutaneous T-cell lymphoma. Eosinophilic fasciitis as a paraneoplastic syndrome of T-cell malignant neoplasms?

Chan, L. S.

doi:10.1001/archderm.127.6.862

Cited by 15 publications

(11 citation statements)

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“…9 In CTCL patients, as well as many other lymphoma patients, concomitant eosinophilia, elevated levels of immunoglobulin (Ig)-E and IgA, and decreased cell-mediated immunity are often observed. 10,11 These complications could be caused by a shift in the cytokine pattern from a T H 1-like to a T H 2-like profile that accompanies progression of CTCL. In this regard, interleukin-5 (IL-5) is the predominant regulator of eosinophilia 12 and has been shown to play an important role in the development of eosinophilia in Hodgkin disease.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Nielsen

Nissen

Gerwien

et al. 2002

Blood

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Mycosis fungoides is a low-grade cutanous T-cell lymphoma (CTCL) of unknown etiology. In advanced stages of CTCL, a shift in cytokine profile from T H 1 to T H 2 is observed, which coincides with eosinophilia, high levels of immunoglobulin E, and increased susceptibility to bacterial infections. It is, however, unknown why T H 2 cytokines predominate in advanced CTCL, and the cellular source of these cytokines also remains to be identified. In several leukemias and lymphomas, constitutively activated signal transducer and activator of transcription (Stat) signaling pathways have been detected. In a previous study, constitutive activation of Stat3 was found in tumor cells isolated from affected skin and blood from CTCL patients. Here, it is shown that CTCL tumor cell lines, but not nonmalignant cell lines, spontaneously produce interleukin-5 (IL-5), IL-6, and IL-13. Transfection of tumor cells with dominantnegative Stat3 almost completely blocks IL-5 production and strongly inhibits IL-13 production, whereas IL-6 production is unaffected. Thus, the data show that malignant CTCL cells themselves might contribute to the change in cytokine pattern accompanying progression of CTCL. In conclusion, constitutively activated Stat3 is found to mediate a spontaneous IL-5 production and regulate IL-13 production in CTCL cell lines, pointing toward a new role of Stat3 in malignant transformation. (Blood. 2002;99:973-977)

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Section: Introductionmentioning

confidence: 99%

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Nielsen

Nissen

Gerwien

et al. 2002

Blood

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“…Pediatric disease, however, has also been documented 3 . EF has been frequently associated with hematological disorders such as aplastic anemia, hemolytic anemia, peripheral autoimmune thrombocytopenia, pernicious anemia, leukemias, and lymphomas 4,5 . Some autoimmune diseases such as Hashimoto's thyroiditis, morphea, systemic sclerosis, Sjogren's syndrome and antiphospholipid antibody syndrome have also been reported in patients with EF 6 .…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Eosinophilic Fasciitis

et al. 2011

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“…Mostly, eosinophilic fasciitis has preceded malignant lymphomas (especially T-cell lymphomas) or occurred simultaneously [1,5,16,25,28,30]. Only a few case reports of an association with low-grade B-cell lymphomas have been published [30].…”

Section: Discussionmentioning

confidence: 99%

l-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia

Böhme

Wolter

Hoelzer

1998

Annals of Hematology

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A female patient presenting with B-CLL and coincident eosinophilia-myalgia syndrome (EMS) after ingestion of L-tryptophan is described. The manifestations of EMS disappeared completely during treatment with cyclophosphamide/prednisone. and there was an intermittent clinical remission of CLL with absence of the monoclonal B-cell population. A few years later, the B-CLL relapsed, but without sign and symptoms of EMS. Whereas other eosinophilic syndromes such as eosinophilic fasciitis, panniculitis, or cellulitis Wells have been found to occur in relation to malignant underlying diseases, only a single patient with malignant fibrous histiocytoma following EMS has been described. There are no reports about an increased occurrence of B-CLL or other non-Hodgkin's lymphomas combined with or following EMS or related to L-tryptophan itself. The variant types of eosinophilic syndromes occurring due to malignant disorders, the differentiation from EMS, and the possible association between B-CLL and L-tryptophan-related EMS are discussed.

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Concurrent eosinophilic fasciitis and cutaneous T-cell lymphoma. Eosinophilic fasciitis as a paraneoplastic syndrome of T-cell malignant neoplasms?

Cited by 15 publications

References 0 publications

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Two Cases of Eosinophilic Fasciitis

l-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia

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