Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions

Arias, Katherine; Baig, Moiz; Colangelo, Marc; Chu, Derek K.; Walker, Tina D.; Goncharova, Susanna; Coyle, Anthony J.; Vadas, Peter; Waserman, Susan; Jordana, Manel

doi:10.1016/j.jaci.2009.03.012

Cited by 98 publications

(71 citation statements)

References 26 publications

(31 reference statements)

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“…Use of a PAF receptor antagonist in a peanut-sensitized murine model significantly lessened the severity and length of anaphylaxis compared with those treated with antihistamines and untreated mice. 43 The combination of the antagonist with antihistamines further improved the results.…”

Section: Cellular Mediatorsmentioning

confidence: 97%

“…43 PAF is regulated in the circulation by the enzyme PAF acetylhydrolase (PAFA). Vadas et al 44 studied PAF and PAFA levels in 41 patients with nonfatal anaphylaxis and compared them to 9 patients with fatal anaphylaxis to peanuts and 5 other groups: nonallergic adults, nonallergic children, healthy children with mild peanut allergy, patients with nonfatal acute anaphylaxis to peanuts, and children who died of causes unrelated to anaphylaxis.…”

Section: Cellular Mediatorsmentioning

confidence: 99%

See 1 more Smart Citation

Potential therapies for peanut allergy

Stahl¹,

Rans²

2011

Annals of Allergy, Asthma & Immunology

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Section: Cellular Mediatorsmentioning

confidence: 97%

Section: Cellular Mediatorsmentioning

confidence: 99%

Potential therapies for peanut allergy

Stahl¹,

Rans²

2011

Annals of Allergy, Asthma & Immunology

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“…Arias et al 10 found that blockade of PAF prevented severe reactions, and blockage of both PAF and histamine had an even greater effect. Lopez-Exposito et al 11 noted that peanut-induced anaphylaxis on first exposure in offspring of peanutsensitized mice was associated with peanut-specific IgG1 levels and was blocked by a PAF antagonist.…”

Section: Pathophysiology Allergen Characterization and Diagnosismentioning

confidence: 98%

“…With regard to the importance of mediators in anaphylaxis, 2 additional murine studies 10,11 of anaphylaxis to peanut emphasize a crucial role of PAF. Arias et al 10 found that blockade of PAF prevented severe reactions, and blockage of both PAF and histamine had an even greater effect.…”

Section: Pathophysiology Allergen Characterization and Diagnosismentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009

Sicherer¹,

Leung²

2010

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis and hypersensitivity reactions to foods, drugs, and insects, as well as advances in allergic skin disease that were reported in the Journal in 2009. Among key epidemiologic observations, several westernized countries report that more than 1% of children have peanut allergy, and there is some evidence that environmental exposure to peanut is a risk factor. The role of regulatory T cells, complement, platelet-activating factor, and effector cells in the development and expression of food allergy were explored in several murine models and human studies. Delayed anaphylaxis to mammalian meats appears to be related to IgE binding to the carbohydrate moiety galactose-alpha-1,3-galactose, which also has implications for hypersensitivity to murine mAb therapeutics containing this oligosaccharide. Oral immunotherapy studies continue to show promise for the treatment of food allergy, but determining whether the treatment causes tolerance (cure) or temporary desensitization remains to be explored. Increased baseline serum tryptase levels might inform the risk of venom anaphylaxis and might indicate a risk for mast cell disorders in persons who have experienced such episodes. Reduced structural and immune barrier function contribute to local and systemic allergen sensitization in patients with atopic dermatitis, as well as increased propensity of skin infections in these patients. The use of increased doses of nonsedating antihistamines and potential usefulness of omalizumab for chronic urticaria was highlighted. These exciting advances reported in the Journal can improve patient care today and provide insights on how we can improve the diagnosis and treatment of these allergic diseases in the future.

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“…Preclinical studies in mice indicate that both histamine and PAF are necessary for severe anaphylaxis and that these are derived primarily from mast cells Arias et al, 2009Arias et al, , 2011. Studies in human subjects using an antiIgE antibody with different kinetics of suppression of basophil and mast cell reactivity have suggested that basophils also contribute to allergic reactions to peanut (Savage et al, 2012).…”

Section: Pathophysiology Of Allergic Reactions To Foodsmentioning

confidence: 99%