Concordance of Adherence Measurement Using Self-Reported Adherence Questionnaires and Medication Monitoring Devices: An Updated Review

Abstract

Results from our review are consistent with previous studies, as we found that many of our studies produced moderate to high correlation between both SRQs and monitoring devices [Farmer, Clin Ther 21(6):1074-90 (1999), IMS Institute for Healthcare Informatics. Avoidable costs in US health care (2012), Patel et al., Respirology 18(3):546-52 (2013), Siracusa et al., J Cyst Fibros 14(5):621-6 (2015), Smith et al., Int J Cardiol 145(1):122-3 (2010)]. Our findings demonstrate that self-reported adherence produces comparable results to electronic monitoring devices. As there is not yet a 'gold standard' measure for monitoring patient adherence, SRQs and Medication Event Monitoring Systems (MEMS) operating together continue to emerge as the preferred effective method for measuring medication adherence.

Accuracy and concordance of measurement methods to assess non-adherence after renal transplantation - a prospective study

“…Overall, highest correlations could be found for TM ± 30 min. As suggested by previous literature [32], self-reports and EM seem to produce similar results on NA which leads to the conclusion that they measure the same construct. Since the highest accuracy was reached for the strictest measure of NA (TM ± 30 min), it can be assumed that small deviations from the dosing schedule are generally reported by patients.…”

“…Studies on the correlations of EM with other adherence measures show mixed results. In a review on adherence in a general population, a high to moderate concordance between EM and self-reports could be found [32], whereas another review found selfreports to be systematically underestimating NA compared to EM [33]. Studies examining the correlations of different adherence measures in RTRs are sparse.…”

Evaluation of tools for annual capture of adherence to immunosuppressive medications after renal transplantation - a single-centre open prospective trial

“…Recent pharmacokinetic simulation data indicate that AE4 h may be more relevant [40]. However, self-reported adherence is often underreported [17,41,42], which may advocate for continuing the use of AE2 h. To our knowledge, there are no data comparing 2-vs. 4-h time windows on longterm outcomes. *The result is significant with P-value 0.05 or less (2-tailed).…”

Regularity of self-reported daily dosage of mood stabilizers and antipsychotics in patients with bipolar disorder

“…All data were self-reported. However, review articles about the measurement of medication adherence have found moderate-to-high concordance between self-reported patient questionnaires and diaries, and electronic monitoring (Garber et al 2004 ; Shi et al 2010 ; Monnette et al 2018 ). In a study of patients with bipolar disorder, good agreement was found between patient questionnaires and serum levels of psychotropic medications (Jónsdóttir et al 2010 ).…”