Concomitant radio- and fluorescence-guided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-99mTc-nanocolloid

Berg, Nynke S. van den; Brouwer, Oscar R.; Klop, W. Martin C.; Karakullukcu, Bariş; Zuur, Charlotte L.; Tan, I. Bing; Balm, Alfons J. M.; Brekel, M.W.M. van den; Olmos, Renato A. Valdés; Leeuwen, Fijs W. B. van

doi:10.1007/s00259-012-2129-5

Cited by 155 publications

(102 citation statements)

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“…Because of the short range of the b 1 -particles, however, detailed preoperative anatomic localization is a prerequisite, which may be provided by PET/CT. Another promising approach for intraoperative detection is the use of near-infrared fluorescence imaging, which should also be able to identify SNs near the injection site (12)(13)(14). The different techniques have to be clinically evaluated in order to conclude which is best suited for intraoperative SN detection.…”

Section: Discussionmentioning

confidence: 99%

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

et al. 2013

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With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using 89 Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of 89 Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using 99m Tc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of 89 Zr-nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using 89 Zr-nanocolloidal albumin is feasible.Key Words: sentinel node; PET/CT; 89 Zr; Nanocoll; head and neck cancer J Nucl Med 2013; 54:585-589 DOI: 10.2967/jnumed.112.115188Sent inel nodes (SNs) near a primary tumor can be hidden by the high amount of radioactivity at the injection site. In such cases, the resolution of planar lymphoscintigraphy and SPECT/CT is limited (1). For oral cancer, this is especially true for tumors located in the floor of the mouth that drain to lingual lymph nodes or level I lymph nodes (2,3), which may explain the significantly lower sensitivity of the SN procedure for floor-of-mouth tumors than for other sites in the oral cavity (80% vs. 97%) (4).PET provides dynamic 3-dimensional information at a higher spatial resolution and, thus, improves anatomic localization-of particular importance in the complex anatomy of the neck, with its abundant lymph nodes (i.e., about 150 on each side). In addition, improved visualization of lymphatic vessels may result in better differentiation between first-and second-echelon lymph nodes. Therefore, we hypothesized that PET might perform better than g-camera-based techniques.Recently, we developed 89 Zr-nanocolloidal albumin for lymphatic mapping and SN detection using PET/CT. The potential of this tracer was shown preclinically in a rabbit lymphogenic metastasis model (5).The present study aimed to evaluate the feasibility of PET/ CT lymphoscintigraphy using 89 Zr-nanocolloidal albumin in patients with early-stage oral cavity carcinoma and to obtain initial clinical experience in a head-to-head comparison with g-camera-based imaging using 99m Tc-nanocolloidal albumin. MATERIALS AND METHODS PatientsThe study included 5 previously untreated patients with earlystage oral cancer who were scheduled for transoral excision and the SN procedure. Each patient had a clinically negative neck as assessed by ultrasound-guided fine-needle aspiration cytology. Three of the patients had a paramedian floor-of-mouth carcinoma, and 2 had a lateral tongue carcinoma. Th...

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Section: Discussionmentioning

confidence: 99%

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

et al. 2013

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“…Alternative to navigating toward an SN, one may also think of using this approach for hybrid tracer-based radioguided occult lesion localization (or for a seed-localization setup wherein hybrid marker seeds are applied) (16,17). PET-based navigation in combination with intraoperative Cerenkov imaging could also provide an interesting extension (18).…”

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Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting

et al. 2016

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With the introduction of the hybrid tracer indocyanine green (ICG)-99m Tc-nanocolloid, a direct relation between preoperative imaging and intraoperative fluorescence guidance was established. However, fluorescence guidance remains limited by its superficial nature. This study evaluated the feasibility of a nuclear medicinebased navigation concept that allowed intraoperative positioning of a fluorescence camera (FC) in the vicinity of preoperatively defined ICG-99m Tc-nanocolloid containing sentinel nodes (SNs). Methods: Five patients with penile cancer scheduled for SN biopsy were injected with ICG-99m Tc-nanocolloid followed by preoperative SPECT/CT imaging. The navigation device was used to provide a real-time augmented reality overlay of the SPECT/CT images and video output of the FC. This overlay was then used for FC navigation.

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“…Yapılan çalışmalarda hibrit radyofarmasötikler tek başına Tc-99m-nanokolloide üstün olarak bulunmuştur. Bu teknik mavi boya ihtiyacını ortadan kaldırmış ve özellikle enjeksiyon bölgesine yakın lenf nodlarını saptamada gama proba göre çok daha başarılı olarak bulunmuştur (21,22). Hibrit bileşiklerin önümüzdeki yıllarda daha yaygın olarak kullanılması beklenmektedir.…”

Section: Sentinellenfbezii̇şaretlemetekniği Aradyofarmasötiklerunclassified

Sentinel Lymph Node Biopsy: Actual Approaches

Tuncel¹,

Salancı²,

Bozkurt³

2017

Nts

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Öz Abstract GirişKanser yayılımında en önemli yollardan biri lenfatik yayılımdır. On yedinci yüzyılda lenfatik sistemin tanımlanması ve ardından kanserdeki rolünün saptanmaya başlaması ile bu konuda çeşitli çalışmalar yapılmıştır. Bu araştırmaların sonucunda bugün kanserin yerleştiği bölgeye bağlı olarak önce bölgesel lenf bezlerine ilerlediği ve klinik tanıdan çok daha önce bu bölgesel lenf bezlerinde mikrometastazların gerçekleştiği bilinmektedir. Bu bilgi özellikle meme kanseri ve malign melanom gibi kanserlerde sentinel lenf bezi (SLB) kavramının doğmasını sağlamıştır (1). İlk SLB tanımı Cabanas tarafından penil kanserde yapılmıştır (2). Lenfosintigrafinin SLB saptanmasında kullanılması Chiappa ve ark.'nın 1966'da testiküler kanserlerde yaptığı çalışma ile başlamıştır (3). Morton ve ark.'nın 194 malign melanom hastasında lenfosintigrafi kullanılarak lenfatik yayılımın araştırdığı çalışma SLB'nin örneklemesinin önünü açmış olup, günümüzde SLB sintigrafisi rutin uygulama kılavuzlarında yerini almıştır (4). Meme kanserlerinde de Christensen ve ark. ile başlayan çalışmalar koruyucu meme cerrahisi uygulamalarının yaygınlaşmasına ve hastaların daha az cerrahi komplikasyon ile tedavi edilmelerine olanak vermiştir (5). Son yıllarda gelişen görüntüleme ve intraoperatif deteksiyon teknolojileri sayesinde SLB biyopsisinin (SLBB) başarısı ve kullanım sıklığı

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Concomitant radio- and fluorescence-guided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-99mTc-nanocolloid

Cited by 155 publications

References 30 publications

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting

Sentinel Lymph Node Biopsy: Actual Approaches

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Concomitant radio- and fluorescence-guided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-99mTc-nanocolloid

Cited by 155 publications

References 30 publications

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with 89Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with 89Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting

Sentinel Lymph Node Biopsy: Actual Approaches

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Product

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Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients