Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer

Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone

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Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone

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Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas

“…However, achieving a temperature above median of T50 for the patients where temperature was recorded in tumours, resulted in a significant better RFS. Our findings support general reviews demonstrating that hyperthermia in addition to its own effect, is a sensitizer for radiation [27,[53][54][55] as well as a chemosensitizer [53]. For further details on mechanism of action of hyperthermia, see references [12,53,56].…”

Short-course preoperative radiotherapy combined with chemotherapy, delayed surgery and local hyperthermia for rectal cancer: a phase II study

“…The impact of radiosensitizers on tumour regression remains unclear and needs to be tested in a randomised setting. Local hyperthermia is a promising novel agent for rectal cancer treatment [27], and the limited data available on its clinical application shows improved tumour regression [11,28]. In our study we did not observe higher pCR rate in a subgroup of patients who received local hyperthermia.…”

Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone

“……”

Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas

“…However, achieving a temperature above median of T50 for the patients where temperature was recorded in tumours, resulted in a significant better RFS. Our findings support general reviews demonstrating that hyperthermia in addition to its own effect, is a sensitizer for radiation [27,[53][54][55] as well as a chemosensitizer [53]. For further details on mechanism of action of hyperthermia, see references [12,53,56].…”

Short-course preoperative radiotherapy combined with chemotherapy, delayed surgery and local hyperthermia for rectal cancer: a phase II study

“…The impact of radiosensitizers on tumour regression remains unclear and needs to be tested in a randomised setting. Local hyperthermia is a promising novel agent for rectal cancer treatment [27], and the limited data available on its clinical application shows improved tumour regression [11,28]. In our study we did not observe higher pCR rate in a subgroup of patients who received local hyperthermia.…”

Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone

“……”

Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas

“…However, achieving a temperature above median of T50 for the patients where temperature was recorded in tumours, resulted in a significant better RFS. Our findings support general reviews demonstrating that hyperthermia in addition to its own effect, is a sensitizer for radiation [27,[53][54][55] as well as a chemosensitizer [53]. For further details on mechanism of action of hyperthermia, see references [12,53,56].…”

Short-course preoperative radiotherapy combined with chemotherapy, delayed surgery and local hyperthermia for rectal cancer: a phase II study

“…The impact of radiosensitizers on tumour regression remains unclear and needs to be tested in a randomised setting. Local hyperthermia is a promising novel agent for rectal cancer treatment [27], and the limited data available on its clinical application shows improved tumour regression [11,28]. In our study we did not observe higher pCR rate in a subgroup of patients who received local hyperthermia.…”