Abstract:Carboxyethyl hydroxychromans
(CEHCs) are natural metabolites of
vitamin E (VE). Their urinary levels can serve as useful biomarkers
for the nutritional assessment of VE. Moreover, specific biological
activities of CEHCs deserve further investigation. Here, we report
a concise method to build up a chiral 6-hydroxychroman scaffold of
VE and CEHCs. The first total synthesis of (
S
)-δ-CEHC
was accomplished in 40% overall yield and 97%
ee
using
a chiral synthon derived… Show more
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