Concerning the Cerebellar Symptoms Produced by Suprasellar Tumors

Harvey Cushing’s craniopharyngioma treatment: Part 1. Identification and clinicopathological characterization of this challenging pituitary tumor

“…14 continued to employ Erdheim's term in his pathological studies on Cushing's CP cases. 1,3,37 Throughout most of the 1920s, Cushing preferentially employed the misnamed terms "pharyngeal pouch cyst" or "craniopharyngeal pouch cyst" despite the well-established concept that the adenohypophyseal primordium, or Rathke's pouch, originates from the embryo's primitive buccal cavity (stomodeal epithelium), not from the pharynx. 27,39 Cushing himself picked the catchy term "craniopharyngioma" in 1929, adding the Greek suffix "-oma" (meaning "swelling" or "tumor") to the combination of "cranio" and "pharynx," and he employed it for the first time in the patient B.L.E.…”

Harvey Cushing’s craniopharyngioma treatment: Part 1. Identification and clinicopathological characterization of this challenging pituitary tumor

“…14 continued to employ Erdheim's term in his pathological studies on Cushing's CP cases. 1,3,37 Throughout most of the 1920s, Cushing preferentially employed the misnamed terms "pharyngeal pouch cyst" or "craniopharyngeal pouch cyst" despite the well-established concept that the adenohypophyseal primordium, or Rathke's pouch, originates from the embryo's primitive buccal cavity (stomodeal epithelium), not from the pharynx. 27,39 Cushing himself picked the catchy term "craniopharyngioma" in 1929, adding the Greek suffix "-oma" (meaning "swelling" or "tumor") to the combination of "cranio" and "pharynx," and he employed it for the first time in the patient B.L.E.…”

Development of intracranial approaches for craniopharyngiomas: an analysis of the first 160 historical procedures

“…Table 1 features a summary of data corresponding to the fundamental epidemiological, surgical, and pathological variables selected and analyzed for the 160 CPs. 1,2,6,7,[9][10][11]13,[15][16][17]19,20,[22][23][24][25]27,[29][30][31][32][34][35][36]40,41,[44][45][46][47][48][49][50][51][52][54][55][56]64,66,68,69,71,72,[74][75][76]78,82,84,…”

“…Cushing was at first reluctant to use ventriculography, a fact that helps to explain the high number of palliative subtemporal decompressions and failed suboccipital explorations he performed in patients with CPs and other pituitary tumors during the first half of the 1920s. 6,7,22,29,31 Evidence of these misdiagnoses is provided in some of the intraventricular tumor cases reported in the review by Fulton and Bailey, most of them surgically addressed by Cushing during the 2nd decade of the 20th century. 60 As a result, the concept of a broadly suprasellar topography for CPs was favored.…”

“…Percival Bailey (1892-1973), a long-term Cushing assistant at Peter Bent Brigham Hospital, who helped him to develop the field of neuropathology, had numerous publications on CPs in which a major concept inherited from Cushing's observations was affirmed-the concept that CPs are true hypothalamic rather than suprasellar lesions. [6][7][8] Bailey also took a special interest in the hypersomnolence and other symptoms related to hypothalamic dysfunction presumably caused by lesions developing within the third ventricle, such as the cerebellar-like disturbances that were particularly frequent in cases diagnosed in adults. 6 In an excellent and exhaustive monograph created in collaboration with the physiologist John Farquhar Fulton (1899-1960), a close friend and the biographer of Harvey Cushing, Bailey provided evidence of the relationship between symptoms such as adiposity, gait ataxia, body temperature dysregulation, and mental or emotional alterations and the dysfunction of definite nuclei or pathways within the hypothalamus caused by the expansion of third ventricle masses.…”

Displacement of mammillary bodies by craniopharyngiomas involving the third ventricle: surgical-MRI correlation and use in topographical diagnosis

“…A rare symptom, not exceptionally reported among CPs involving the third ventricle, was the occurrence of gait disturbances in approximately 10% of cases, which can also be related to dysfunction of subthalamic nuclei/pathways. 5 Unequivocal description of the histological type of CP was provided in the report of 69 lesions (53.1%) included in this cohort. A majority of CPs corresponded to the adamantinomatous variant (79.7%), whereas 20.3% corresponded to the squamous-papillary type, the latter very rarely observed among wholly suprasellar (extraventricular) CPs.…”

Harvey Cushing’s craniopharyngioma treatment: Part 1. Identification and clinicopathological characterization of this challenging pituitary tumor

“…14 continued to employ Erdheim's term in his pathological studies on Cushing's CP cases. 1,3,37 Throughout most of the 1920s, Cushing preferentially employed the misnamed terms "pharyngeal pouch cyst" or "craniopharyngeal pouch cyst" despite the well-established concept that the adenohypophyseal primordium, or Rathke's pouch, originates from the embryo's primitive buccal cavity (stomodeal epithelium), not from the pharynx. 27,39 Cushing himself picked the catchy term "craniopharyngioma" in 1929, adding the Greek suffix "-oma" (meaning "swelling" or "tumor") to the combination of "cranio" and "pharynx," and he employed it for the first time in the patient B.L.E.…”

Development of intracranial approaches for craniopharyngiomas: an analysis of the first 160 historical procedures

“…Table 1 features a summary of data corresponding to the fundamental epidemiological, surgical, and pathological variables selected and analyzed for the 160 CPs. 1,2,6,7,[9][10][11]13,[15][16][17]19,20,[22][23][24][25]27,[29][30][31][32][34][35][36]40,41,[44][45][46][47][48][49][50][51][52][54][55][56]64,66,68,69,71,72,[74][75][76]78,82,84,…”

“…Cushing was at first reluctant to use ventriculography, a fact that helps to explain the high number of palliative subtemporal decompressions and failed suboccipital explorations he performed in patients with CPs and other pituitary tumors during the first half of the 1920s. 6,7,22,29,31 Evidence of these misdiagnoses is provided in some of the intraventricular tumor cases reported in the review by Fulton and Bailey, most of them surgically addressed by Cushing during the 2nd decade of the 20th century. 60 As a result, the concept of a broadly suprasellar topography for CPs was favored.…”

“…Percival Bailey (1892-1973), a long-term Cushing assistant at Peter Bent Brigham Hospital, who helped him to develop the field of neuropathology, had numerous publications on CPs in which a major concept inherited from Cushing's observations was affirmed-the concept that CPs are true hypothalamic rather than suprasellar lesions. [6][7][8] Bailey also took a special interest in the hypersomnolence and other symptoms related to hypothalamic dysfunction presumably caused by lesions developing within the third ventricle, such as the cerebellar-like disturbances that were particularly frequent in cases diagnosed in adults. 6 In an excellent and exhaustive monograph created in collaboration with the physiologist John Farquhar Fulton (1899-1960), a close friend and the biographer of Harvey Cushing, Bailey provided evidence of the relationship between symptoms such as adiposity, gait ataxia, body temperature dysregulation, and mental or emotional alterations and the dysfunction of definite nuclei or pathways within the hypothalamus caused by the expansion of third ventricle masses.…”

Displacement of mammillary bodies by craniopharyngiomas involving the third ventricle: surgical-MRI correlation and use in topographical diagnosis

“…A rare symptom, not exceptionally reported among CPs involving the third ventricle, was the occurrence of gait disturbances in approximately 10% of cases, which can also be related to dysfunction of subthalamic nuclei/pathways. 5 Unequivocal description of the histological type of CP was provided in the report of 69 lesions (53.1%) included in this cohort. A majority of CPs corresponded to the adamantinomatous variant (79.7%), whereas 20.3% corresponded to the squamous-papillary type, the latter very rarely observed among wholly suprasellar (extraventricular) CPs.…”

Harvey Cushing’s craniopharyngioma treatment: Part 1. Identification and clinicopathological characterization of this challenging pituitary tumor

“…14 continued to employ Erdheim's term in his pathological studies on Cushing's CP cases. 1,3,37 Throughout most of the 1920s, Cushing preferentially employed the misnamed terms "pharyngeal pouch cyst" or "craniopharyngeal pouch cyst" despite the well-established concept that the adenohypophyseal primordium, or Rathke's pouch, originates from the embryo's primitive buccal cavity (stomodeal epithelium), not from the pharynx. 27,39 Cushing himself picked the catchy term "craniopharyngioma" in 1929, adding the Greek suffix "-oma" (meaning "swelling" or "tumor") to the combination of "cranio" and "pharynx," and he employed it for the first time in the patient B.L.E.…”

Development of intracranial approaches for craniopharyngiomas: an analysis of the first 160 historical procedures

“…Table 1 features a summary of data corresponding to the fundamental epidemiological, surgical, and pathological variables selected and analyzed for the 160 CPs. 1,2,6,7,[9][10][11]13,[15][16][17]19,20,[22][23][24][25]27,[29][30][31][32][34][35][36]40,41,[44][45][46][47][48][49][50][51][52][54][55][56]64,66,68,69,71,72,[74][75][76]78,82,84,…”

“…Cushing was at first reluctant to use ventriculography, a fact that helps to explain the high number of palliative subtemporal decompressions and failed suboccipital explorations he performed in patients with CPs and other pituitary tumors during the first half of the 1920s. 6,7,22,29,31 Evidence of these misdiagnoses is provided in some of the intraventricular tumor cases reported in the review by Fulton and Bailey, most of them surgically addressed by Cushing during the 2nd decade of the 20th century. 60 As a result, the concept of a broadly suprasellar topography for CPs was favored.…”

“…Percival Bailey (1892-1973), a long-term Cushing assistant at Peter Bent Brigham Hospital, who helped him to develop the field of neuropathology, had numerous publications on CPs in which a major concept inherited from Cushing's observations was affirmed-the concept that CPs are true hypothalamic rather than suprasellar lesions. [6][7][8] Bailey also took a special interest in the hypersomnolence and other symptoms related to hypothalamic dysfunction presumably caused by lesions developing within the third ventricle, such as the cerebellar-like disturbances that were particularly frequent in cases diagnosed in adults. 6 In an excellent and exhaustive monograph created in collaboration with the physiologist John Farquhar Fulton (1899-1960), a close friend and the biographer of Harvey Cushing, Bailey provided evidence of the relationship between symptoms such as adiposity, gait ataxia, body temperature dysregulation, and mental or emotional alterations and the dysfunction of definite nuclei or pathways within the hypothalamus caused by the expansion of third ventricle masses.…”

Displacement of mammillary bodies by craniopharyngiomas involving the third ventricle: surgical-MRI correlation and use in topographical diagnosis

“…A rare symptom, not exceptionally reported among CPs involving the third ventricle, was the occurrence of gait disturbances in approximately 10% of cases, which can also be related to dysfunction of subthalamic nuclei/pathways. 5 Unequivocal description of the histological type of CP was provided in the report of 69 lesions (53.1%) included in this cohort. A majority of CPs corresponded to the adamantinomatous variant (79.7%), whereas 20.3% corresponded to the squamous-papillary type, the latter very rarely observed among wholly suprasellar (extraventricular) CPs.…”