Concept of Visible Mesh and Possibilities for Analysis of Mesh Migration and Shrinkage

Conception d’un treillis anti-infectieux et visible en IRM pour la prise en charge chirurgicale des prolapsus génitaux et des hernies abdominales

“…Ces dernières années, quelques équipes de recherche tentent d'incorporer des systèmes au sein de treillis afin de les localiser en IRM, mais à ce jour très peu de résultats sont concluants [24,25]. La stratégie chimique développée au laboratoire a permis de greffer de manière durable un complexant du Gd 3+ (le DTPA), sur le squelette de polymère dégradable (PCL) ou biostable (PAM) pour viser des applications biomédicales temporaires ou permanentes [12,13].…”

Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio-Functionality to Meshes

“…The idea behind this concept is to be able to diagnose clinical complications frequently observed after mesh implantation, such as shrinkage, tissue erosion, mesh migration and deformation, and for the surgeons to follow the fate of the allogenic material using non‐invasive imaging techniques and consequently to be able to reposition the material if required. It is extremely challenging, or even impossible, with the current clinical imaging devices, such as X‐ray or computerized tomography (CT scan), ultra‐sound and magnetic resonance imaging (MRI), to directly localize the implanted material after its infiltration by the host tissue . Among the different established techniques used clinically to diagnose pathologies and diseases occurring in the human body, MRI is one of the most powerful and widespread techniques.…”

“…Using MRI, two main techniques have been investigated depending on the nature of the contrast agent incorporated in the mesh structure (superparamagnetic iron oxides (SPIO) or paramagnetic gadolinium (Gd)‐based agents). The first illustration is shown by Otto and co‐workers who created a MRI‐visible mesh made of nanoparticles of SPIO dispersed into the bulk material of the mesh (PVDF) before the extrusion of filaments and weaving ( Figure A–C) . After implantation, the authors were able to discriminate the mesh from the tissue (due to hypo‐intense demarcation) and to delineate the area of the composite iron‐loaded mesh using a specific T2‐sequence (Figure D,E).…”