Concentric left ventricular remodelling is associated with subclinical systolic dysfunction in patients with psoriatic arthritis

Giollo, Alessandro; Farina, Nicola; Cioffi, Giovanni; Ognibeni, Federica; Dalbeni, Andrea; Orsolini, Giovanni; Idolazzi, Luca; Gatti, Davide; Rossini, Maurizio; Viapiana, Ombretta

doi:10.1080/03009742.2020.1739328

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…The impact of psoriasis on the risk of chronic heart failure (CHF) has been noted in a previous national study and was also found to be positively correlated with the severity of psoriasis 33 . However, left ventricular remodelling and a decrease in ejection fraction have only been discovered in studies on psoriatic arthritis 34 . Packer and colleagues have summarized the inflammatory metabolic heart failure with preserved ejection fraction potentially caused by systemic inflammation such as psoriasis, suggesting that the related mechanisms may be akin to the pro‐inflammatory metabolic syndrome that may predominate in coronary syndrome events 35 …”

Section: Discussionmentioning

confidence: 95%

“…33 However, left ventricular remodelling and a decrease in ejection fraction have only been discovered in studies on psoriatic arthritis. 34 Packer and colleagues have summarized the inflammatory metabolic heart failure with preserved ejection fraction potentially caused by systemic inflammation such as psoriasis, suggesting that the related mechanisms may be akin to the proinflammatory metabolic syndrome that may predominate in coronary syndrome events. 35 Interleukin-17 (IL-17), Interleukin-23 (IL-23) and the type I inflammation they mediate are widely recognized as pivotal drivers of the systemic inflammatory response in psoriasis.…”

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confidence: 99%

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Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study

Kan,

Chen,

Tao

et al. 2024

Experimental Dermatology

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The association between psoriasis and cardiovascular disease (CVD) has long been discussed and continually refined. However, there is currently a lack of prospective studies on the cardiovascular risk attributed to psoriasis in the United States general population. Representative adult participants were selected from the National Health and Nutrition Examination Survey (NHANES). Risks of cardiovascular symptoms and diseases prevalence were evaluated between participants with and without psoriasis. The hazards for all‐cause mortality and CVD mortality were stratified by psoriasis status. Mediation analysis was then conducted to identify potential mediators between psoriasis and cardiac death. Overall, 19 741 participants were included in the current study, 542 (2.7%) had psoriasis and 19 199 (97.3%) did not have psoriasis. After adjusting for known CVD risk factors, odds for hypertension (OR = 1.37, 95% CI: 1.13–1.66, p = 0.001), hypercholesterolemia (OR = 1.37, 95% CI: 1.13–1.64, p < 0.001) and angina pectoris (OR = 1.74, 95% CI: 1.11–2.60, p = 0.011) were higher in psoriasis patients. Compared with participants without psoriasis, moderate/severe but not mild patients showed significantly higher CVD mortality (HR = 2.55, 95% CI: 1.27–5.15, p = 0.009). This result was supported by subgroup analyses. Mediation analysis further suggested that the direct effect of moderate/severe psoriasis on CVD mortality accounted for 81.4% (65.8%–97.1%). Besides, the indirect effect might derive from disturbance of serum albumin, urea nitrogen and uric acid. Moderate‐to‐severe psoriasis is an independent risk factor for cardiovascular disease, making it necessary to regularly conduct cardiovascular disease‐related examinations for patients with higher severity of psoriasis in clinical settings.

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Section: Discussionmentioning

confidence: 95%

Section: + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + ...mentioning

confidence: 99%

Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study

Kan,

Chen,

Tao

et al. 2024

Experimental Dermatology

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show abstract

“…The impact of psoriasis on the risk of chronic heart failure (CHF) has been noted in a previous national study and was also found to be positively correlated with the severity of psoriasis(36). However, left ventricular remodeling and a decrease in ejection fraction have only been discovered in studies on psoriatic arthritis (37). Packer and colleagues have summarized the in ammatory metabolic heart failure with preserved ejection fraction potentially caused by systemic in ammation such as psoriasis, suggesting that the related mechanisms may be akin to the pro-in ammatory metabolic syndrome that may predominate in coronary syndrome events(38).…”

Section: Discussionmentioning

confidence: 99%

Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: A population-base study

Chen

Kan

Tao

et al. 2023

Preprint

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Background The association between psoriasis and cardiovascular disease (CVD) has long been discussed and continually refined. However, there is currently a lack of prospective studies on the cardiovascular risk attributed to psoriasis in the general population. Methods Representative adult participants were selected from the National Health and Nutrition Examination Survey (NHANES). Risks of cardiovascular symptoms and diseases prevalence were evaluated between participants with and without psoriasis. The hazards for all-cause mortality and CVD mortality were stratified by psoriasis status. Mediation analysis was then conducted to identify potential mediators between psoriasis and cardiac death. Results Overall, 19,741 participants were included in the current study, 542 (2.7%) had psoriasis and 19,199 (97.3%) did not have psoriasis. After adjusting for known CVD risk factors, odds for hypertension (OR = 1.37, 95% CI: 1.13-1.66, p= 0.001), hypercholesterolemia (OR = 1.37, 95% CI: 1.13-1.64, p < 0.001) and angina pectoris (OR = 1.74, 95% CI: 1.11-2.60, p = 0.011) were higher in psoriasis patients. Compared with participants without psoriasis, moderate/severe but not mild patients showed significantly higher CVD mortality (HR = 2.55, 95% CI: 1.27-5.15, p = 0.009). This result was supported by subgroup analyses. Mediation analysis further suggested that the direct effect of moderate/severe psoriasis on CVD mortality accounted for 81.4% (65.8%-97.1%). Besides, the indirect effect might derive from disturbance of serum albumin, urea nitrogen and uric acid. Conclusions Moderate-to-severe psoriasis is an independent risk factor for cardiovascular disease, making it necessary to regularly conduct cardiovascular disease-related examinations for patients with higher severity of psoriasis in clinical settings.

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“…Furthermore, lower LVGLS was associated with larger aortic root diameter [61]. Finally, most asymptomatic SpA patients have concentric LV remodeling, which is closely associated with subclinical left ventricular systolic dysfunction (LVSD) [62]. Echocardiography, although it is an easy, low cost and widely available modality, it has the limitations of operator and acoustic window dependency and cannot perform cardiac tissue characterization [63].…”

Section: Role Of Imaging For Cardiac Assessment In Spamentioning

confidence: 99%

Pathophysiology of Bone and Cardiac Involvement in Spondyloarthropathies: The indispensible value of magnetic resonance imaging

SI¹,

Nikas²,

Bonou³

et al. 2021

Trends Med

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Ankylosing spondylitis (AS) is the commonest expression of SpA. It is 2-3 times more common in men than women. IBP in a young patient is the most frequent symptom, but peripheral arthritis and/or enthesopathy may be found in some patients. Uveitis, positive family history for AS, impaired spinal mobility or chest expansion, all supports the diagnosis of AS [1].Axial involvement is one of the disease characteristics and 90% of patients have radiographic sacroiliitis during the course of the disease. Currently, a patient can be classified as having definite AS, if at least one clinical criterion (IBP, limitation of lumbar spine or limitation of chest expansion) plus a radiologic criterion (bilaterally grade 2 or unilateral grade 3-4 sacroiliitis) are fulfilled [9].

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Concentric left ventricular remodelling is associated with subclinical systolic dysfunction in patients with psoriatic arthritis

Cited by 6 publications

References 35 publications

Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study

Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population‐based study

Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: A population-base study

Pathophysiology of Bone and Cardiac Involvement in Spondyloarthropathies: The indispensible value of magnetic resonance imaging

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