2018
DOI: 10.3892/etm.2018.6782
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Abstract: Rapamycin has been reported to be immunosuppressive and anti-proliferative towards vascular endothelial and smooth muscle cells. The purpose of the present study was to investigate the effects of rapamycin on the biological behaviors of endothelial cells that have been separated from the deformed vein in human venous malformation (VM). Cellular morphology was observed using inverted microscopy. An MTT assay was performed to measure the cell viability at different concentrations of rapamycin and different time … Show more

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Cited by 7 publications
(6 citation statements)
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“…We noted an increase in the number (470. Thus, within the framework of the model used, cells of the EA.Hy926 cell line responded to a higher FCS concentration with increased migratory activity, which is consistent with results described previously [22,66]. This allows evaluation of changes in cell migratory activity in the presence of MVs derived from cells of the NK-92 cell line.…”
Section: Evaluation Of the Effect Of Mvs Derived From Cells Of The Nksupporting
confidence: 87%
“…We noted an increase in the number (470. Thus, within the framework of the model used, cells of the EA.Hy926 cell line responded to a higher FCS concentration with increased migratory activity, which is consistent with results described previously [22,66]. This allows evaluation of changes in cell migratory activity in the presence of MVs derived from cells of the NK-92 cell line.…”
Section: Evaluation Of the Effect Of Mvs Derived From Cells Of The Nksupporting
confidence: 87%
“…3 (470.8, 592.3), p < 0.01) and the decrease in the residual area of the disrupted monolayer line after cell migration (0.16 (0.14, 0.22), p < 0.05) mm 2 . Thus, data of control samples (2.5% FBS and 10% FBS shown as median (interquartile range)) about number of migrated endothelial cells and area after cell migration allow to conclude that cells of the EA.hy926 cell line responded to a higher FBS concentration with the increased migratory activity, which is consistent with results described previously [70,71]. This allows the evaluation of changes in endothelial cell migratory activity in the presence of MVs derived from cells of the NK-92 cell line.…”
Section: Evaluation Of the Effect Of Mvs Derived From Cells Of The Nk...supporting
confidence: 90%
“…Besides induction of autophagy, rapamycin also affects other signaling pathways, including glycolysis and cell growth (89). Rapamycin has concentration-dependent effects (87,(90)(91)(92)(93). Considering the potential immunosuppressive effects of rapamycin at higher doses (94), we intentionally chose a low-dose rapamycin treatment regimen that has been shown to improve T cell responses (64) and extend the lifespan in murine models (95)(96)(97).…”
Section: Discussionmentioning
confidence: 99%